| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bartolo, Paulo
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2024Biomimetic dual sensing polymer nanocomposite for biomedical applicationscitations
- 2023Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defectscitations
- 2023Rheological behaviour of different composite materials for additive manufacturing of 3D bone scaffoldscitations
- 2022Smart nanostructured materials for tissue engineering
- 2021Green Synthesis of Silver Nanoparticles Using Extract of Cilembu Sweet Potatoes (Ipomoea batatas L var. Rancing) as Potential Filler for 3D Printed Electroactive and Anti-Infection Scaffoldscitations
- 2021In Vivo Investigation of Polymer-Ceramic PCL/HA and PCL/β-TCP 3D Composite Scaffolds and Electrical Stimulation for Bone Regenerationcitations
- 2020Mechanical, biological and tribological behaviour of fixation plates 3D printed by electron beam and selective laser meltingcitations
- 2014Materials characterization for stereolithography
- 2014Fabrication and characterisation of PCL and PCL/PLA scaffolds for tissue engineeringcitations
- 2011Theoretical and Modeling Aspects of Curing Reactionscitations
- 2011Biofabrication of poly(HEMA) scaffolds through stereolithography
- 2011Stereolithographic Processescitations
- 2011History of Stereolithographic Processescitations
- 2009Cristallinity and anisotropy evaluation of polymeric biomaterials for bioextrusion
- 2008Selective laser sintering
- 2007A new phenomenological model to describe the mechanical behaviour of alginate structures for tissue engineering
- 2006Effective modelling for thermoset systems
- 2005Direct and inverse stereolithography problem modeling
- 2005Modelling of reaction kinetic through stereolithography process
- 2005New approach to cure modelling for stereolithography
- 2004Modelling the curing behaviour and morphological studies of polymeric materials for thermal stereolithographic process
- 2003Kinetic modeling of reaction polymerization processes through RIM
- 2003Advanced photo-fabrication system for thermosetting materials
- 2002A new thermal-kinetic and mechanical modelling approach to study curing reactions of thermosetting materials
- 2001Stereolithography heat-transfer and solidification simulation using the finite element method
Places of action
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article
In Vivo Investigation of Polymer-Ceramic PCL/HA and PCL/β-TCP 3D Composite Scaffolds and Electrical Stimulation for Bone Regeneration
Abstract
<jats:p>Critical bone defects are a major clinical challenge in reconstructive bone surgery. Polycaprolactone (PCL) mixed with bioceramics, such as hydroxyapatite (HA) and tricalcium phosphate (TCP), create composite scaffolds with improved biological recognition and bioactivity. Electrical stimulation (ES) aims to compensate the compromised endogenous electrical signals and to stimulate cell proliferation and differentiation. We investigated the effects of composite scaffolds (PCL with HA; and PCL with β-TCP) and the use of ES on critical bone defects in Wistar rats using eight experimental groups: untreated, ES, PCL, PCL/ES, HA, HA/ES, TCP, and TCP/ES. The investigation was based on histomorphometry, immunohistochemistry, and gene expression analysis. The vascular area was greater in the HA/ES group on days 30 and 60. Tissue mineralization was greater in the HA, HA/ES, and TCP groups at day 30, and TCP/ES at day 60. Bmp-2 gene expression was higher in the HA, TCP, and TCP/ES groups at day 30, and in the TCP/ES and PCL/ES groups at day 60. Runx-2, Osterix, and Osteopontin gene expression were also higher in the TCP/ES group at day 60. These results suggest that scaffolds printed with PCL and TCP, when paired with electrical therapy application, improve bone regeneration.</jats:p>