| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Chee, Bor Shin
Athlone Institute of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2021Ti-25Nb-25Ta alloy treated by plasma electrolytic oxidation in phosphoric acid for implant applications
- 2021Ti-25nb-25ta alloy treated by plasma electrolytic oxidation in phosphoric acid for implant applicationscitations
- 2021Development, characterization and cell viability inhibition of pva spheres loaded with doxorubicin and 4′-amino-1-naphthyl-chalcone (D14) for osteosarcomacitations
- 2020Titanium-Niobium (Ti-xNb) alloys with high Nb amounts for applications in biomaterials
- 2020Titanium-Niobium (Ti-xNb) Alloys with High Nb Amounts for Applications in Biomaterialscitations
- 2019Titanium-niobium alloys covered by electrospinning technique to applications in bone implants
- 2019Electrospun hydrogels composites for bone tissue engineering.
- 2019The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system.citations
- 2019The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet systemcitations
- 2018Electrospun hydrogels composites for bone tissue engineeringcitations
Places of action
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article
Development, characterization and cell viability inhibition of pva spheres loaded with doxorubicin and 4′-amino-1-naphthyl-chalcone (D14) for osteosarcoma
Abstract
Chalcones (1,3-diaryl-2-propen-1-ones) are naturally occurring polyphenols with known anticancer activity against a variety of tumor cell lines, including osteosarcoma (OS). In this paper, we present the preparation and characterization of spheres (~2 mm) from polyvinyl alcohol (PVA) containing a combination of 4′-Amino-1-Naphthyl-Chalcone (D14) and doxorubicin, to act as a new polymeric dual-drug anticancer delivery. D14 is a potent inhibitor of osteosarcoma progression and, when combined with doxorubicin, presents a synergetic effect; hence, physically crosslinked PVA spheres loaded with D14 and doxorubicin were prepared using liquid nitrogen and six freeze–thawing cycles. Physical-chemical characterization using a scanning electron microscope (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) presented that the drugs were incorporated into the spheres via weak interactions between the drugs and the polymeric chains, resulting in overall good drug stability. The cytotoxicity activity of the PVA spheres co-encapsulating both drugs was tested against the U2OS human osteosarcoma cell line by 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay, and compared to the spheres carrying either D14 or doxorubicin alone. The co-delivery showed a cytotoxic effect 2.6-fold greater than doxorubicin alone, revealing a significant synergistic effect with a coefficient of drug interaction (CDI) of 0.49. The obtained results suggest this developed PVA sphere as a potential dual-drug delivery system that could be used for the prominent synergistic anticancer activity of co-delivering D14 and doxorubicin, providing a new potential strategy for improved osteosarcoma treatment.