| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Estrade, Sonia
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2021Direct evidence of a graded magnetic interface in bimagnetic core/shell nanoparticles using electron magnetic circular dichroism (EMCD)citations
- 2021Direct Measurement of Oxygen Mass Transport at the Nanoscalecitations
- 2020Reliable Characterization of Organic and Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopycitations
- 2019Zinc blende and wurtzite CoO polymorph nanoparticles : rational synthesis and commensurate and incommensurate magnetic ordercitations
- 2019Independent Tuning of Optical Transparency Window and Electrical Properties of Epitaxial SrVO3 Thin Films by Substrate Mismatchcitations
- 2019Low-power, high-performance, non-volatile inkjet-printed HfO 2 -based resistive random access memory : from device to nanoscale characterizationcitations
- 2018Voltage-controlled ON−OFF ferromagnetism at room temperature in a single metal oxide filmcitations
- 2018Atomic-Scale Determination of Cation Inversion in Spinel-Based Oxide Nanoparticlescitations
- 2017Seeded Growth Synthesis of Au-Fe3O4 Heterostructured Nanocrystals : Rational Design and Mechanistic Insightscitations
- 2017High Electrocatalytic Response of a Mechanically Enhanced NbC Nanocomposite Electrode Toward Hydrogen Evolution Reactioncitations
- 2014Direct evidence for an interdiffused intermediate layer in bi-magnetic core-shell nanoparticlescitations
Places of action
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article
Reliable Characterization of Organic and Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
Abstract
<jats:p>Organic and biological compounds (especially those related to the pharmaceutical industry) have always been of great interest for researchers due to their importance for the development of new drugs to diagnose, cure, treat or prevent disease. As many new API (active pharmaceutical ingredients) and their polymorphs are in nanocrystalline or in amorphous form blended with amorphous polymeric matrix (known as amorphous solid dispersion—ASD), their structural identification and characterization at nm scale with conventional X-Ray/Raman/IR techniques becomes difficult. During any API synthesis/production or in the formulated drug product, impurities must be identified and characterized. Electron energy loss spectroscopy (EELS) at high energy resolution by transmission electron microscope (TEM) is expected to be a promising technique to screen and identify the different (organic) compounds used in a typical pharmaceutical or biological system and to detect any impurities present, if any, during the synthesis or formulation process. In this work, we propose the use of monochromated TEM-EELS, to analyze selected peptides and organic compounds and their polymorphs. In order to validate EELS for fingerprinting (in low loss/optical region) and by further correlation with advanced DFT, simulations were utilized.</jats:p>