| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Barbu, Eugen
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Topics
Publications (11/11 displayed)
- 2019Butylglyceryl pectin nanoparticles: synthesis, formulation and characterizationcitations
- 2019Sustained release from injectable composite gels loaded with silver nanowires designed to combat bacterial resistance in bone regeneration applicationscitations
- 2011Multifunctional poly(alkyl methacrylate) films for dental carecitations
- 2010A thermogravimetric method for assessing the substantivity of polymer films on dentally relevant substratescitations
- 2010Towards the determination of surface energy at the nanoscale: a further assessment of the AFM-based approachcitations
- 2010A comparative study of surface energy data from atomic force microscopy and from contact angle goniometrycitations
- 2008Synthesis and characterization of low surface energy fluoropolymers as potential barrier coatings in oral carecitations
- 2002Poly(di-1H,1H,2H,2H-perfluoroalkylitaconate) filmscitations
- 2002Fluoropolymer coatings with inherent resistance to biofouling
- 2002Impact of Fluorination and Side-Chain Length on Poly(methylpropenoxyalkylsiloxane) and Poly(alkyl methacrylate) Solubility in Supercritical Carbon Dioxidecitations
- 2002Poly(di-1H,1H,2H,2H-perfluoroalkylitaconate) films:surface organisation phenomena, surface energy determinations and force of adhesion measurementscitations
Places of action
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article
Butylglyceryl pectin nanoparticles: synthesis, formulation and characterization
Abstract
Pectin is a polysaccharide with very good gel forming properties that traditionally has found important applications in foods and pharmaceutical industries. Although less studied, chemical modifications of pectin leading to a decrease in its hydrophilicity can be useful for the development of novel drug carriers. To this aim, butylglyceryl pectins (P-OX4) were synthesized via functionalization with <i>n-</i>butylglycidyl ether and subsequently formed into nanoparticles. Chromatographic, spectroscopic, and thermal analytical methods were employed to characterize the novel butylglyceryl pectins (P-OX4) obtained, prior to their formulation into nanoparticles via nanoprecipitation. Nuclear magnetic resonance (NMR) and Fourier transform infrared (FT-IR) spectroscopy confirmed a degree of modification in these materials in the range 10.4–13.6%, and thermal stability studies indicated an increase in both the thermal decomposition onset and glass transition temperature values (compared to those of the original pectin). An increase in the molecular weight and a decrease in the viscosity of P-OX4, when compared to the starting material, were also observed. The resulting nanoformulations were investigated in terms of particle morphology, size and stability, and it was found that particles were roughly spherical, with their size below 300 nm, and a negative zeta potential (−20 to −26 mV, indicating good stability). Having demonstrated the ability to load Doxorubicin at the level of 10%, their potential in drug delivery applications warrants further investigations.