693.932 PEOPLE
| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Boisen, Anja
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (62/62 displayed)
- 2024Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foilscitations
- 2024Fully Biodegradable Elastomer-Based Device for Oral Macromolecule Deliverycitations
- 20233D-printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Deliverycitations
- 2022High-throughput 3d-printing
- 2022Self-propelled Janus micromotors for pH-responsive release of small molecule drugcitations
- 2021Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus filmcitations
- 2021The determinant role of fabrication technique in final characteristics of scaffolds for tissue engineering applications:A focus on silk fibroin-based scaffoldscitations
- 2021Effects of chitosan/chondroitin sulfate polysaccharide lids on amoxicillin drug release from microcontainers
- 2021The determinant role of fabrication technique in final characteristics of scaffolds for tissue engineering applicationscitations
- 2019Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices
- 2019Fast and quantitative 2D and 3D orientation mapping using Raman microscopycitations
- 2019Where Is the Drug? Quantitative 3D Distribution Analyses of Confined Drug-Loaded Polymer Matricescitations
- 2019Thin Film Analysis by Nanomechanical Infrared Spectroscopycitations
- 2019Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopycitations
- 2019Thread-Like Radical-Polymerization via Autonomously Propelled (TRAP) Botscitations
- 2019Pyrolytic carbon resonators for micromechanical thermal analysiscitations
- 2019Wafer-Scale Polymer-Based Transparent Nanocorals with Excellent Nanoplasmonic Photothermal Stability for High-Power and Superfast SERS Imagingcitations
- 2018Using microcantilever sensors to measure poly(lactic-co-glycolic acid) plasticization by moisture uptakecitations
- 2018Evaluation of the effects of spray drying parameters for producing cubosome powder precursorscitations
- 2018Evaluation of the effects of spray drying parameters for producing cubosome powder precursorscitations
- 2018Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanoconescitations
- 2017Microcontainers as an oral delivery system for spray dried cubosomes containing ovalbumincitations
- 2017Quantitative Detection of Trace Level Cloxacillin in Food Samples Using Magnetic Molecularly Imprinted Polymer Extraction and Surface-Enhanced Raman Spectroscopy Nanopillarscitations
- 2016Microcontainers for Intestinal Drug Delivery
- 2016Wafer-Scale Nanopillars Derived from Block Copolymer Lithography for Surface-Enhanced Raman Spectroscopycitations
- 2016Supercritical impregnation of polymer matrices spatially confined in microcontainers for oral drug delivery: Effect of temperature, pressure and timecitations
- 2016Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distributioncitations
- 2016Triple co-culture cell model as an in vitro model for oral particulate vaccine systems
- 2016Nonlinear optomechanical measurement of mechanical motioncitations
- 2015Fabrication of Ni stamp with high aspect ratio, two-leveled, cylindrical microstructures using dry etching and electroplatingcitations
- 2015Microcantilever sensors for fast analysis of enzymatic degradation of poly (D, L-lactide)citations
- 2015Fabrication and loading of oral drug delivery microcontainers using hot punching
- 2015Hot punching of high-aspect-ratio 3D polymeric microstructures for drug deliverycitations
- 2014Physical characterization of photocrosslinked poly(vinyl pyrrolidone) (PVP) hydrogels for drug delivery
- 2014Single-layer graphene on silicon nitride micromembrane resonatorscitations
- 2014Single-layer graphene on silicon nitride micromembrane resonatorscitations
- 2014Micromechanical String Resonators: Analytical Tool for Thermal Characterization of Polymerscitations
- 2013Spray coating of microcontainers with eudragit using ferromagnetic shadow masks for controlled oral release of poorly water soluble drugs.
- 2013Sensitive determination of the Young's modulus of thin films by polymeric microcantileverscitations
- 2013Plasma etching on large-area mono-, multi- and quasi-mono crystalline silicon
- 2013Plasma etching on large-area mono-, multi- and quasi-mono crystalline silicon
- 2013Biodegradable microcontainers as an oral drug delivery system for poorly soluble drugs.
- 2013Ferromagnetic shadow mask for spray coating of polymer patternscitations
- 2013Process optimization of ultrasonic spray coating of polymer filmscitations
- 2013DNA hybridization sensing for cytogenetic analysis
- 2012Process Optimization for Spray Coating of Poly (vinyl pyrrolidone)
- 2011Microwave absorption properties of gold nanoparticle doped polymerscitations
- 2011Biodegradable micromechanical sensors
- 2011Fabrication and characterization of SRN/SU-8 bimorph cantilevers for temperature sensingcitations
- 2010Double layer resist process scheme for metal lift-off with application in inductive heating of microstructurescitations
- 2008Optimized plasma-deposited fluorocarbon coating for dry release and passivation of thin SU-8 cantileverscitations
- 2007Reliability of poly 3,4-ethylenedioxythiophene strain gaugecitations
- 2007Single-mode waveguides with SU-8 polymer core and cladding for MOEMS applicationscitations
- 2005Investigation of the bond strength between the photo-sensitive polymer SU-8 and gold
- 2005Dry release of all-polymer structurescitations
- 2005Highly Sensitive Polymer-based Cantilever-sensors for DNA Detectioncitations
- 2004Investigation of the bond strength between the photo-sensitive polymer SU-8 and Au
- 2003Polymeric mechanical sensors with strain gauge readout in a microfluidic system
- 2003Polymeric cantilever arrays for biosensing applicationscitations
- 2003Polymeric Cantilever Arrays for Biosensing Applicationscitations
- 2003Optimised cantilever biosensor with piezoresistive read-outcitations
- 2002Adsorption kinetics and mechanical properties of thiol-modified DNA-oligos on gold investigated by microcantilever sensorscitations
Places of action
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article
Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils
Abstract
<p>Ingestible self-configurable proximity-enabling devices have been developed as a non-invasive platform to improve the bioavailability of drug compounds via swellable or self-unfolding devices. Self-unfolding foils support unidirectional drug release in close proximity to the intestinal epithelium, the main drug absorption site following oral administration. The foils are loaded with a solid-state formulation containing the active pharmaceutical ingredient and then coated and rolled into enteric capsules. The coated lid must remain intact to ensure drug protection in the rolled state until targeted release in the small intestine after capsule disintegration. Despite promising results in previous studies, the deposition of an enteric top coating that remains intact after rolling is still challenging. In this study, we compare different mixtures of enteric polymers and a plasticizer, PEG 6000, as potential coating materials. We evaluate mechanical properties as well as drug protection and targeted release in gastric and intestinal media, respectively. Commercially available Eudragit<sup>®</sup> FL30D-55 appears to be the most suitable material due to its high strain at failure and integrity after capsule fitting. In vitro studies of coated foils in gastric and intestinal media confirm successful pH-triggered drug release. This indicates the potential advantage of the selected material in the development of self-unfolding foils for oral drug delivery.</p>