| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mertz, Damien
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2024Tailoring the pore structure of iron oxide core@stellate mesoporous silica shell nanocomposites: effects on MRI and magnetic hyperthermia properties and applicability to anti-cancer therapiescitations
- 2023Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studiescitations
- 2023Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studiescitations
- 2023Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties-From Suspension to In Vitro Studies.citations
- 2023Phosphate Capture Enhancement Using Designed Iron Oxide-Based Nanostructurescitations
- 2023UV-Accelerated Synthesis of Gold Nanoparticle–Pluronic Nanocomposites for X-ray Computed Tomography Contrast Enhancementcitations
- 2023High temperature flow synthesis of iron oxide Nanoparticles: Size tuning via reactor engineering
- 2022Near-infrared Responsive Nanocomposite Hydrogels Made from Enzyme-Coated Carbon Nanotubes@ Large Pore Mesoporous Silica for Remotely Triggered Drug Deliverycitations
- 2022Peptide Hydrogels Assembled from Enzyme-Adsorbed Mesoporous Silica Nanostructures for Thermoresponsive Doxorubicin Releasecitations
- 2021Iron Stearate Structures: An Original Tool for Nanoparticles Designcitations
- 2020Elaboration of Superparamagnetic and Bioactive Multicore–Shell Nanoparticles (γ-Fe 2 O 3 @SiO 2 -CaO): A Promising Material for Bone Cancer Treatmentcitations
- 2020Harnessing Composition of Iron Oxide Nanoparticle: Impact of Solvent-Mediated Ligand–Ligand Interaction and Competition between Oxidation and Growth Kineticscitations
- 2020Near infra-red light responsive carbon nanotubes@mesoporous silica for photothermia and drug delivery to cancer cellscitations
- 2019Fluorescent and magnetic stellate mesoporous silica for bimodal imaging and magnetic hyperthermiacitations
- 2019Doxorubicin-Loaded Thermoresponsive Superparamagnetic Nanocarriers for Controlled Drug Delivery and Magnetic Hyperthermia Applicationscitations
- 2019Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivocitations
- 2011Nanoengineered films via surface-confined continuous assembly of polymerscitations
Places of action
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article
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties—From Suspension to In Vitro Studies
Abstract
<jats:p>Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of the size and the shape of IONPs is of tremendous importance to develop theranostic nanoobjects displaying efficient MRI contrast agents and hyperthermia agent via the combination of magnetic hyperthermia (MH) and/or photothermia (PTT). Another key parameter is that the amount of accumulation of IONPs in cancerous cells is sufficiently high, which often requires the grafting of specific targeting ligands (TLs). Herein, IONPs with nanoplate and nanocube shapes, which are promising to combine magnetic hyperthermia (MH) and photothermia (PTT), were synthesized by the thermal decomposition method and coated with a designed dendron molecule to ensure their biocompatibility and colloidal stability in suspension. Then, the efficiency of these dendronized IONPs as contrast agents (CAs) for MRI and their ability to heat via MH or PTT were investigated. The 22 nm nanospheres and the 19 nm nanocubes presented the most promising theranostic properties (respectively, r2 = 416 s−1·mM−1, SARMH = 580 W·g−1, SARPTT = 800 W·g−1; and r2 = 407 s−1·mM−1, SARMH = 899 W·g−1, SARPTT = 300 W·g−1). MH experiments have proven that the heating power mainly originates from Brownian relaxation and that SAR values can remain high if IONPs are prealigned with a magnet. This raises hope that heating will maintain efficient even in a confined environment, such as in cells or in tumors. Preliminary in vitro MH and PTT experiments have shown the promising effect of the cubic shaped IONPs, even though the experiments should be repeated with an improved set-up. Finally, the grafting of a specific peptide (P22) as a TL for head and neck cancers (HNCs) has shown the positive impact of the TL to enhance IONP accumulation in cells.</jats:p>