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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Lazzeri, A.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2024Toughened Vinyl Ester Resin Reinforced with Natural Flax Fabrics
- 2023Investigation of new Poly(lactic acid) (PLA)/Poly(butylene succinate-co-adipate) (PBSA) thermoplastic composites reinforced with different amount of twill hemp fabricscitations
- 2023Chitin nanofibrils modulate mechanical response in tympanic membrane replacementscitations
- 2022Biobased functional coatings for cellulosic substrates
- 2022Size effect of carbon fiber-reinforced silicon carbide composites (C/C-SiC): Part 2 - tensile testing with alignment devicecitations
- 2021On the use of paper sludge as filler in biocomposites for injection mouldingcitations
- 2021Chitin Nanofibril Application in Tympanic Membrane Scaffolds to Modulate Inflammatory and Immune Responsecitations
- 2021Design of an overmoded resonant cavity-based reactor for ceramic matrix composites productioncitations
- 2021Investigation of electric field-aligned edge-oxidized graphene oxide nanoplatelets in polyethersulfone matrix in terms of pure water permeation and dye rejectioncitations
- 2020Electrospun ZnO/Poly(Vinylidene Fluoride-Trifluoroethylene) Scaffolds for Lung Tissue Engineeringcitations
- 2020Evaluation of mussel shells powder as reinforcement for pla-based biocompositescitations
- 2020A proposal to modify the Kelly-Tyson equation to calculate the interfacial shear strength (IFSS) of composites with low aspect ratio fiberscitations
- 2020Bio-based packaging: Materials, modifications, industrial applications and sustainabilitycitations
- 2020Thermoplastic Blends Based on Poly(Butylene Succinate-co-Adipate) and Different Collagen Hydrolysates from Tanning Industry: I—Processing and Thermo-mechanical Propertiescitations
- 2020Electrospun ZnO/Poly(Vinylidene fluoride-trifluoroethylene) scaffolds for lung tissue engineeringcitations
- 2020Effect of a bio-based dispersing aid (EINAR® 101) on pla-arbocel® biocomposites: Evaluation of the interfacial shear stress on the final mechanical propertiescitations
- 2019Composites Based On PHB-HV and Saw Dust Fibers for Terrestrial Applications: Processability and Degradability
- 2019Thermal, mechanical, and rheological properties of biocomposites made of poly(Lactic acid) and potato pulp powdercitations
- 2019Flat die extruded biocompatible poly(lactic acid) (PLA)/poly(butylene succinate) (PBS) Based Filmscitations
- 2019Flat die extruded biocompatible poly(lactic acid) (PLA)/poly(butylene succinate) (PBS) Based Filmscitations
- 2019Thermo-mechanical properties of PLA/short flax fiber biocompositescitations
- 2017Green composites based on PHA and natural fibres for applications in marine and land environmentscitations
- 2016EUROPEAN PROJECT “NANO-CATHEDRAL: NANOMATERIALS FOR CONSERVATION OF EUROPEAN ARCHITECTURAL HERITAGE DEVELOPED BY RESEARCH ON CHARACTERISTIC LITHOTYPES”
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article
Chitin Nanofibril Application in Tympanic Membrane Scaffolds to Modulate Inflammatory and Immune Response
Abstract
Chitin nanofibrils (CNs) are an emerging bio-based nanomaterial. Due to nanometric size and high crystallinity, CNs lose the allergenic features of chitin and interestingly acquire anti-inflammatory activity. Here we investigate the possible advantageous use of CNs in tympanic membrane (TM) scaffolds, as they are usually implanted inside highly inflamed tissue environment due to underlying infectious pathologies. In this study, the applications of CNs in TM scaffolds were twofold. A nanocomposite was used, consisting of poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT) copolymer loaded with CN/polyethylene glycol (PEG) pre-composite at 50/50 (w/w %) weight ratio, and electrospun into fiber scaffolds, which were coated by CNs from crustacean or fungal sources via electrospray. The degradation behavior of the scaffolds was investigated during 4 months at 37 degrees C in an otitis-simulating fluid. In vitro tests were performed using cell types to mimic the eardrum, i.e., human mesenchymal stem cells (hMSCs) for connective, and human dermal keratinocytes (HaCaT cells) for epithelial tissues. HMSCs were able to colonize the scaffolds and produce collagen type I. The inflammatory response of HaCaT cells in contact with the CN-coated scaffolds was investigated, revealing a marked downregulation of the pro-inflammatory cytokines. CN-coated PEOT/PBT/(CN/PEG 50:50) scaffolds showed a significant indirect antimicrobial activity.