| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Gebert, Annett
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (43/43 displayed)
- 2024Tribocorrosion behaviour of additively manufactured β-type Ti–Nb alloy for implant applications
- 2024Electrochemical Surface Nanostructuring of Ti<sub>47</sub>Cu<sub>38</sub>Fe<sub>2.5</sub>Zr<sub>7.5</sub>Sn<sub>2</sub>Si<sub>1</sub>Ag<sub>2</sub> Metallic Glass for Improved Pitting Corrosion Resistancecitations
- 2024Acid Treatments of Ti-Based Metallic Glasses for Improving Corrosion Resistance in Implant Applications
- 2024Tailoring microstructure and mechanical properties of an LPBF-processed beta Ti-Nb alloy through post-heat treatmentscitations
- 2023Experimental and numerical characterization of imperfect additively manufactured lattices based on triply periodic minimal surfacescitations
- 2023Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys
- 2023Shape optimization of additively manufactured lattices based on triply periodic minimal surfacescitations
- 2023Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications : Composite Characterization and Cytocompatibility Assessmentcitations
- 2023Designing Gallium-Containing Hydroxyapatite Coatings on Low Modulus Beta Ti-45Nb Alloy
- 2023Laser interference-treatment tunes surface states and corrosion behavior of additively manufactured near-beta Ti alloy
- 2023Fine-tuning effect of Direct Laser Interference Patterning on the surface states and the corrosion behavior of a biomedical additively manufactured beta Ti alloycitations
- 2023Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications:citations
- 2023Influence of isothermal omega precipitation aging on deformation mechanisms and mechanical properties of a β-type Ti-Nb alloycitations
- 2023Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment
- 2023Tribocorrosion behavior of β-type Ti-Nb-Ga alloys in a physiological solutioncitations
- 2022Controlling the Young’s modulus of a ß-type Ti-Nb alloy via strong texturing by LPBFcitations
- 2022Novel low modulus beta-type Ti–Nb alloys by gallium and copper minor additions for antibacterial implant applications
- 2022Functionalization of Ti-40Nb implant material with strontium by reactive sputtering
- 2022From infrared to ultraviolet: Direct laser interference patterning of additively manufactured titanium alloy using a picosecond laser
- 2022Designing the microstructural constituents of an additively manufactured near β Ti alloy for an enhanced mechanical and corrosion responsecitations
- 2022Anelastic-like nature of the rejuvenation of metallic glasses by cryogenic thermal cycling
- 2022Fabrication of four-level hierarchical topographies through the combination of LIPSS and direct laser interference pattering on near-beta titanium alloycitations
- 2021Improved corrosion behavior of a novel Fe85Cr4Mo8V2C1 tool steel processed by laser powder bed fusioncitations
- 2020A comparative study of the influence of the deposition technique (electrodeposition versus sputtering) on the properties of nanostructured Fe70Pd30 filmscitations
- 2020Effect of Selective Laser Melting on Microstructure, Mechanical, and Corrosion Properties of Biodegradable FeMnCS for Implant Applicationscitations
- 2020Correlations between the ductility and medium-range order of bulk metallic glassescitations
- 2020Tailoring biocompatible Ti-Zr-Nb-Hf-Si metallic glasses based on high-entropy alloys design approach
- 2020A comparative study of the influence of the deposition technique (electrodeposition versus sputtering) on the properties of nanostructured Fe70 Pd30 filmscitations
- 2020Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materialscitations
- 2020Electrodeposition of Sr-substituted hydroxyapatite on low modulus beta-type Ti-45Nb and effect on in vitro Sr release and cell responsecitations
- 2019Cyclic deformation characteristics of the metastable v-type Ti-40Nb alloycitations
- 2019Electrodeposition of Sr-substituted hydroxyapatite on low modulus beta-type Ti-45Nb and effect on in vitro Sr release and cell response
- 2018Corrosion studies on Fe-30Mn-1C alloy in chloride-containing solutions with view to biomedical applicationcitations
- 2018Effects of thermomechanical history and environment on the fatigue behavior of (v)-Ti-Nb implant alloyscitations
- 2017Corrosion Fatigue Studies on a Bulk Glassy Zr-Based Alloy under Three-Point Bending
- 2017Fatigue properties of a new generation ß-type Ti-Nb alloy for osteosynthesis with an industrial standard surface conditioncitations
- 2017Functionalization of Ti-40Nb implant material with strontium by reactive sputteringcitations
- 2016Anodically fabricated TiO2–SnO2 nanotubes and their application in lithium ion batteriescitations
- 2016Designing new biocompatible glass-forming Ti₇₅ˍₓ Zr₁₀ Nbₓ Si₁₅ (x = 0, 15) alloys : corrosion, passivity, and apatite formationcitations
- 2013Production of porous β-Type Ti–40Nb alloy for biomedical applications: Comparison of selective laser melting and hot pressingcitations
- 2013Thermal stability and phase transformations of martensitic Ti-Nb alloyscitations
- 2010Magnetoelectrochemical surface structuringcitations
- 2010Electrocrystallisation of CoFe alloys under the influence of external homogeneous magnetic fields-Properties of deposited thin filmscitations
Places of action
| Organizations | Location | People |
|---|
article
Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials
Abstract
The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of polyelectrolyte complex (PEC) nanoparticle (NP) based on electrostatic interactions between charged drug and polyelectrolyte (PEL) to a DDS concept involving covalent bonding between PEL and uncharged drugs. For this purpose, 3,4-dihydroxyphenyl acetic acid (DOPAC) was polymerized via an oxidatively induced coupling reaction. This novel chemo-reactive polyanion PDOPAC is able to temporarily bind boronic acid groups of BZM via its catechol groups, through esterification. PDOPAC was admixed to poly(l-glutamic acid) (PLG) and poly(l-lysine) (PLL) forming a redispersible PEC NP system after centrifugation, which is advantageous for further colloid and BZM loading processing. It was found that the loading capacity (LC) strongly depends on the PDOPAC and catechol content in the PEC NP. Furthermore, the type of loading and the net charge of the PEC NP affect LC and the residual content (RC) after release. Release experiments of PDOPAC/PEC coatings were performed at medically relevant bone substitute materials (calcium phosphate cement and titanium niobium alloy) whereby the DDS worked independently of the surface properties. Additionally, in contrast to electrostatically based drug loading the release behavior of covalently bound, uncharged BZM is independent of the ionic strength (salt content) in the release medium. ; publishedVersion