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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Goyanes, Alvaro
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2023Electrophotographic 3D printing of pharmaceutical films
- 2022Prediction of Solid-State Form of SLS 3D Printed Medicines Using NIR and Raman Spectroscopy
- 2020Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetroncitations
- 20203D printingcitations
- 20203D printed opioid medicines with alcohol-resistant and abuse-deterrent propertiescitations
- 2019Direct powder extrusion 3D printing: Fabrication of drug products using a novel single-step process.citations
- 2019Track-and-trace: Novel anti-counterfeit measures for 3D printed personalized drug products using smart material inks.citations
- 20193D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technologycitations
- 20183D printing of drug-loaded gyroid lattices using selective laser sinteringcitations
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article
Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron
Abstract
<jats:p>The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.</jats:p>