| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Lamprou, Dimitrios A.
Queen's University Belfast
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (22/22 displayed)
- 2023Combining microfluidics and coaxial 3D-bioprinting for the manufacturing of diabetic wound healing dressingscitations
- 2023Combining microfluidics and coaxial 3D-bioprinting for the manufacturing of diabetic wound healing dressingscitations
- 2023Urethane dimethacrylate-based photopolymerizable resins for stereolithography 3D printing: a physicochemical characterisation and biocompatibility evaluationcitations
- 20223D bioprinted scaffolds for diabetic wound healing applicationscitations
- 2022Stereolithography 3D printed implants: a preliminary investigation as potential local drug delivery systems to the earcitations
- 2022High spatial resolution ToF-SIMS imaging and image analysis strategies to monitor and quantify early phase separation in amorphous solid dispersionscitations
- 2022Fused deposition modeling 3D printing proof of concept study for personalised inner ear therapycitations
- 2021Fused deposition modelling for the development of drug loaded cardiovascular prosthesiscitations
- 2021Microfluidics Technology for the Design and Formulation of Nanomedicinescitations
- 2021Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular graftscitations
- 2021Microfluidics technology for the design and formulation of nanomedicinescitations
- 20203D printing of drug-loaded thermoplastic polyurethane meshes: A potential material for soft tissue reinforcement in vaginal surgerycitations
- 20193D printed microneedle patches using stereolithography (SLA) for intradermal insulin deliverycitations
- 2017Fabrication and characterisation of drug-loaded electrospun polymeric nanofibers for controlled release in hernia repaircitations
- 2017A novel methodology to study polymodal particle size distributions produced during continuous wet granulationcitations
- 2017Probing polydopamine adhesion to protein and polymer films : microscopic and spectroscopic evaluation
- 2017Isatin thiosemicarbazones promote honeycomb structure formation in spin-coated polymer films: concentration effect and release studiescitations
- 2017Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluationcitations
- 2016A novel hot-melt extrusion formulation of albendazole for increasing dissolution propertiescitations
- 2016Isatin thiosemicarbazone-blended polymer films for biomedical applications : surface morphology, characterisation and preliminary biological assessmentcitations
- 2014The degradative effects of germicidal light on flexible endoscope material
- 2012Polymer templating of supercooled indomethacin for polymorph selectioncitations
Places of action
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article
3D printing of drug-loaded thermoplastic polyurethane meshes: A potential material for soft tissue reinforcement in vaginal surgery
Abstract
Pelvic Organ Prolapse (POP) or Stress Urinary Incontinence (SUI) are two very common disorders affecting 30-40% of women worldwide. Current strategies to repair or improve these medical conditions are non-surgical options such as physiotherapy, or surgical options such as the use surgical vaginal meshes. The use of the latter has caused some complications such as chronic pain, infection or mesh rupture. Accordingly, a novel approach that does not show such problems is required. Additive manufacturing (AM) technology, also known as 3D-printing was employed to manufacture these new vaginal meshes. For this purpose, thermoplastic polyurethane (TPU) filaments containing levofloxacin (LFX) in various concentrations (e.g., 0, 0.25, 0.5, and 1%) were produced by an extrusion process. The extruded filaments were used in a fused deposition modeling (FDM) 3D printer to print the abovementioned vaginal meshes. The printed meshes were fully characterized trough different test/analysis such as fracture force studies, attenuated total reflection-Fourier transform infrared, thermal analysis, scanning electron microscopy, X-ray microcomputer tomography (μCT) analysis, release studies in phosphate-buffered saline, and microbiology studies. The results showed that LFX was uniformly distributed within the TPU matrix, regardless the concentration tested. The mechanical properties showed that poly(propylene) (PP) is a tougher material with lower elasticity than TPU which seemed to be a more suitable material due to its elasticity. In addition, the printed meshes showed a significant bacteriostatic activity on both Staphylococcus aureus and Escherichia coli cultures minimising the risk of infection after implanting them. Therefore, the incorporation of LFX to the TPU matrix can be used to prepare anti-infective vaginal meshes with enhanced mechanical properties compared with current PP vaginal meshes.