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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Teske, Michael
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2022Characterization of Ball-milled Poly(Nisopropylacrylamide) Nanogels
- 2022The influence of PEGDA’s molecular weight on its mechanical properties in the context of biomedical applicationscitations
- 2021A hydrogel based quasi-stationary test system for in vitro dexamethasone release studies for middle ear drug delivery systems
- 2020Smart releasing electrospun nanofibers-poly: L.lactide fibers as dual drug delivery system for biomedical application.citations
- 2020PEGDA drug delivery scaffolds manufactured with a novel hybrid AM process
- 20193D-printed PEGDA structure with multiple depots for advanced drug delivery systems
- 2019A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots. citations
- 2019Thermomechanical properties of PEGDA in combination with different photo-curable comonomerscitations
- 2019Controlled biodegradation of metallic biomaterials by plasma polymer coatings using hexamethyldisiloxane and allylamine monomerscitations
- 2018Thermomechanical properties of PEGDA and its co-polymerscitations
- 2018Novel approach for a PTX/VEGF dual drug delivery system in cardiovascular applications-an innovative bulk and surface drug immobilization.citations
- 2017Osteointegration of Porous Poly-ε-Caprolactone-Coated and Previtalised Magnesium Implants in Critically Sized Calvarial Bone Defects in the Mouse Model. citations
- 2017In Vitro Evaluation of PCL and P(3HB) as Coating Materials for Selective Laser Melted Porous Titanium Implants. citations
- 2017Influence of bulk incorporation of FDAc and PTX on polymer propertiescitations
- 2015Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL
- 2015Surface Modification of Biodegradable Polymers towards Better Biocompatibility and Lower Thrombogenicity.citations
- 2015Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL.citations
- 2015SLM produced porous titanium implant improvements for enhanced vascularization and osteoblast seeding.citations
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article
A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots.
Abstract
Here, we present a new hybrid additive manufacturing (AM) process to create drug delivery systems (DDSs) with selectively incorporated drug depots. The matrix of a DDS was generated by stereolithography (SLA), whereas the drug depots were loaded using inkjet printing. The novel AM process combining SLA with inkjet printing was successfully implemented in an existing SLA test setup. In the first studies, poly(ethylene glycol) diacrylate-based specimens with integrated depots were generated. As test liquids, blue and pink ink solutions were used. Furthermore, bovine serum albumin labeled with Coomassie blue dye as a model drug was successfully placed in a depot inside a DDS. The new hybrid AM process makes it possible to place several drugs independently of each other within the matrix. This allows adjustment of the release profiles of the drugs depending on the size as well as the position of the depots in the DDS.