| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Barbu, Eugen
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2019Butylglyceryl pectin nanoparticles: synthesis, formulation and characterizationcitations
- 2019Sustained release from injectable composite gels loaded with silver nanowires designed to combat bacterial resistance in bone regeneration applicationscitations
- 2011Multifunctional poly(alkyl methacrylate) films for dental carecitations
- 2010A thermogravimetric method for assessing the substantivity of polymer films on dentally relevant substratescitations
- 2010Towards the determination of surface energy at the nanoscale: a further assessment of the AFM-based approachcitations
- 2010A comparative study of surface energy data from atomic force microscopy and from contact angle goniometrycitations
- 2008Synthesis and characterization of low surface energy fluoropolymers as potential barrier coatings in oral carecitations
- 2002Poly(di-1H,1H,2H,2H-perfluoroalkylitaconate) filmscitations
- 2002Fluoropolymer coatings with inherent resistance to biofouling
- 2002Impact of Fluorination and Side-Chain Length on Poly(methylpropenoxyalkylsiloxane) and Poly(alkyl methacrylate) Solubility in Supercritical Carbon Dioxidecitations
- 2002Poly(di-1H,1H,2H,2H-perfluoroalkylitaconate) films:surface organisation phenomena, surface energy determinations and force of adhesion measurementscitations
Places of action
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article
Sustained release from injectable composite gels loaded with silver nanowires designed to combat bacterial resistance in bone regeneration applications
Abstract
One-dimensional nanostructures such as silver nanowires (AgNWs) have attracted considerable attention owing to their outstanding electrical, thermal and antimicrobial properties; however, their application in the prevention of infections linked to bone tissue regeneration interventions has not yet been explored. Here we report on the development of an innovative scaffold prepared from chitosan, composite hydroxyapatite and AgNWs (CS-HACS-AgNWs) having both bioactive and antibacterial properties. In vitro results highlighted the antibacterial potential of AgNWs against both gram-positive and gram-negative bacteria. The CS-HACS-AgNWs composite scaffold demonstrated suitable Ca/P deposition, improved gel strength, reduced gelation time, and sustained Ag+ release within therapeutic concentrations. Antibacterial studies showed that the composite formulation was capable of inhibiting bacterial growth in suspension and of completely preventing biofilm formation on the scaffold in the presence of resistant strains. The hydrogels were also shown to be biocompatible, allowing cell proliferation. In summary, the developed CS-HACS-AgNWs composite hydrogels demonstrated significant potential as a scaffold material to be employed in bone regenerative medicine, as it presents enhanced mechanical strength combined with the ability to allow calcium salts deposition, while efficiently decreasing the risk of infections. The results presented justify further investigations into potential clinical applications of these materials.