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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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King, Andrew
Salford Royal NHS Foundation Trust
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (27/27 displayed)
- 2024Impact of flax fibre micro-structural features on composite damage observed through micro-CT characterisationcitations
- 2023Local Structure and Density of Liquid Fe‐C‐S Alloys at Moon's Core Conditionscitations
- 2023A Novel Multi-Model High Spatial Resolution Method for Analysis of DCE MRI Data: Insights from Vestibular Schwannoma Responses to Antiangiogenic Therapy in Type II Neurofibromatosiscitations
- 2023Environment effect on internal fatigue crack propagation studied with in-situ X-ray microtomographycitations
- 2022Internal fatigue crack monitoring during ultrasonic fatigue test using temperature measurements and tomographycitations
- 2022Internal fatigue crack monitoring during ultrasonic fatigue test using temperature measurements and tomographycitations
- 2022Quantitative thermomechanical characterisation of 3D-woven SiC/SiC composites from in-situ tomographic and thermographic imagingcitations
- 2022In situ tomographic study of a 3D-woven SiC/SiC composite part subjected to severe thermo-mechanical loadscitations
- 2021Tomography Imaging of Lithium Electrodeposits Using Neutron, Synchrotron X-ray, and Laboratory X-ray sources: A Comparisoncitations
- 2021In Situ Imaging Comparison of Lithium Electrodeposits By Neutron and X-Ray (Synchrotron and Laboratory) Tomographycitations
- 2021Microstructural evolution in deforming olivine-serpentine aggregates at subduction zones conditions using in-situ X-ray tomography
- 2021A new high-pressure technique for the measurement of low frequency seismic attenuation using cyclic torsional loadingcitations
- 2020TiC-MgO composite: an X-ray transparent and machinable heating element in a multi-anvil high pressure apparatuscitations
- 2020Reevaluation of metal interconnectivity in a partially molten silicate matrix using 3D microtomographycitations
- 2020In situ synchrotron ultrasonic fatigue testing device for 3D characterisation of internal crack initiation and growthcitations
- 2019Analysis of the damage initiation in a SiC/SiC composite tube from a direct comparison between large-scale numerical simulation and synchrotron X-ray micro-computed tomographycitations
- 2019Strain localization in ductile shear zones: This is a crystal plasticity's world, but it wouldn't be nothing without a micro-cracking or a sliding grain
- 2019Crystal slip and Grain Sliding: a two-stroke engine driving ductile localization
- 2018Time dependent voiding mechanisms in polyamide 6 submitted to high stress triaxiality : experimental characterisation and finite element modellingcitations
- 2017In-situ synchrotron X-ray radiography observation of primary Al2Cu intermetallic growth on fragments of aluminium oxide filmcitations
- 2017A synchrotron X-radiography study of the fragmentation and refinement of primary intermetallic particles in an Al-35 Cu alloy induced by ultrasonic melt processingcitations
- 2016Massively parallel FFT-based simulation to analyze the behavior of architected SiC/SiC composite tubes from synchrotron X-ray tomography
- 2014Investigation of fatigue crack propagation in nickel superalloy using Diffraction contrast tomography and Phase Contrast tomographycitations
- 2013Advances in X-ray diffraction contrast tomography: flexibility in the setup geometry and application to multiphase materialscitations
- 2013X-ray diffraction contrast tomography: a combined 3D imaging and diffraction methodology for characterization of polycristalline materials
- 20113-D growth of a short fatigue crack within a polycrystalline microstructure studied using combined diffraction and phase-contrast X-ray tomographycitations
- 20113D growth of a short fatigue crack within a polycrystalline microstructure studied using combined diffraction and phase-contrast X-ray tomographycitations
Places of action
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article
A Novel Multi-Model High Spatial Resolution Method for Analysis of DCE MRI Data: Insights from Vestibular Schwannoma Responses to Antiangiogenic Therapy in Type II Neurofibromatosis
Abstract
<p>This study aimed to develop and evaluate a new DCE-MRI processing technique that combines LEGATOS, a dual-temporal resolution DCE-MRI technique, with multi-kinetic models. This technique enables high spatial resolution interrogation of flow and permeability effects, which is currently challenging to achieve. Twelve patients with neurofibromatosis type II-related vestibular schwannoma (20 tumours) undergoing bevacizumab therapy were imaged at 1.5 T both before and at 90 days following treatment. Using the new technique, whole-brain, high spatial resolution images of the contrast transfer coefficient (K<sup>trans</sup>), vascular fraction (v<sub>p</sub>), extravascular extracellular fraction (v<sub>e</sub>), capillary plasma flow (F<sub>p</sub>), and the capillary permeability-surface area product (PS) could be obtained, and their predictive value was examined. Of the five microvascular parameters derived using the new method, baseline PS exhibited the strongest correlation with the baseline tumour volume (p = 0.03). Baseline v<sub>e</sub> showed the strongest correlation with the change in tumour volume, particularly the percentage tumour volume change at 90 days after treatment (p < 0.001), and PS demonstrated a larger reduction at 90 days after treatment (p = 0.0001) when compared to K<sup>trans</sup> or F<sub>p</sub> alone. Both the capillary permeability-surface area product (PS) and the extravascular extracellular fraction (v<sub>e</sub>) significantly differentiated the ‘responder’ and ‘non-responder’ tumour groups at 90 days (p < 0.05 and p < 0.001, respectively). These results highlight that this novel DCE-MRI analysis approach can be used to evaluate tumour microvascular changes during treatment and the need for future larger clinical studies investigating its role in predicting antiangiogenic therapy response.</p>