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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Popov, Alexey
VTT Technical Research Centre of Finland
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2024SnS2 Thin Film with In Situ and Controllable Sb Doping via Atomic Layer Deposition for Optoelectronic Applicationscitations
- 2021From Cyclopentasilane to Thin‐Film Transistorscitations
- 2021Dimethylammonium iodide stabilized bismuth halide perovskite photocatalyst for hydrogen evolutioncitations
- 2018Markers of Oxidative Stress in the Exhaled Breath Condensate of Workers Handling Nanocompositescitations
- 2018Partial magnetic ordering in one-dimensional arrays of endofullerene single-molecule magnet peapodscitations
- 2018Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workerscitations
- 2017Polycyclic heteroaromatic hydrocarbons containing a benzoisoindole corecitations
- 2014Titania nanofibers in gypsum compositescitations
- 2014Gold nanostructures for OCT imaging of capillary flowcitations
- 2013Growth of all-carbon horizontally aligned single-walled carbon nanotubes nucleated from fullerene-based structurescitations
- 2013Plasmon-resonant gold nanoparticles with variable morphology as optical labels and drug carriers for cytological researchcitations
- 2012Understanding High-Yield Catalyst-Free Growth of Horizontally Aligned Single-Walled Carbon Nanotubes Nucleated by Activated C <sub>60</sub> Speciescitations
- 2011Growth of catalyst-assisted and catalyst-free horizontally aligned single wall carbon nanotubescitations
Places of action
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article
Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers
Abstract
<jats:p>Thousands of researchers and workers worldwide are employed in nanocomposites manufacturing, yet little is known about their respiratory health. Aerosol exposures were characterized using real time and integrated instruments. Aerosol mass concentration ranged from 0.120 mg/m3 to 1.840 mg/m3 during nanocomposite machining processes; median particle number concentration ranged from 4.8 × 104 to 5.4 × 105 particles/cm3. The proportion of nanoparticles varied by process from 40 to 95%. Twenty employees, working in nanocomposite materials research were examined pre-shift and post-shift using spirometry and fractional exhaled nitric oxide (FeNO) in parallel with 21 controls. Pro-inflammatory leukotrienes (LT) type B4, C4, D4, and E4; tumor necrosis factor (TNF); interleukins; and anti-inflammatory lipoxins (LXA4 and LXB4) were analyzed in their exhaled breath condensate (EBC). Chronic bronchitis was present in 20% of researchers, but not in controls. A significant decrease in forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) was found in researchers post-shift (p ˂ 0.05). Post-shift EBC samples were higher for TNF (p ˂ 0.001), LTB4 (p ˂ 0.001), and LTE4 (p ˂ 0.01) compared with controls. Nanocomposites production was associated with LTB4 (p ˂ 0.001), LTE4 (p ˂ 0.05), and TNF (p ˂ 0.001), in addition to pre-shift LTD4 and LXB4 (both p ˂ 0.05). Spirometry documented minor, but significant, post-shift lung impairment. TNF and LTB4 were the most robust markers of biological effects. Proper ventilation and respiratory protection are required during nanocomposites processing.</jats:p>