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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Liu, Wei
Universidad de Cantabria
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (20/20 displayed)
- 2024High Current Density Operation of a Proton Exchange Membrane Fuel Cell with Varying Inlet Relative Humidity—A Modeling Studycitations
- 2023Scalable manufacturing of quantum light emitters in silicon under rapid thermal annealingcitations
- 2023The effects of esketamine and treatment expectation in acute major depressive disorder (Expect): study protocol for a pharmacological fMRI study using a balanced placebo designcitations
- 2022Advanced Gene Therapy Strategies for the Repair of ACL Injuries
- 2020Free-Standing Graphene Oxide and Carbon Nanotube Hybrid Papers with Enhanced Electrical and Mechanical Performance and Their Synergy in Polymer Laminatescitations
- 2020Acceleration Factor Modeling of Flexible Electronic Substrates From Actual Human Body Measurements
- 2020Nanomechanics of graphene oxide-bacteriophage based self-assembled porous compositescitations
- 2020Free-standing graphene oxide and carbon nanotube hybrid papers with enhanced electrical and mechanic performance and their synergy in polymer laminatescitations
- 2018Self – supporting Hierarchical Porous PtAg Alloy Nanotubular Aerogels as Highly Active and Durable Electrocatalystscitations
- 2017Multimetallic Hierarchical Aerogels: Shape Engineering of the Building Blocks for Efficient Electrocatalysiscitations
- 2017Stealth Biocompatible Si-Based Nanoparticles for Biomedical Applicationscitations
- 2017Stealth Biocompatible Si-Based Nanoparticles for Biomedical Applicationscitations
- 2017Homogeneity and Elemental Distribution in Self-Assembled Bimetallic Pd-Pt Aerogels prepared by a spontaneous one-step gelation processcitations
- 2016Gold aerogels: Three-dimensional assembly of nanoparticles and their use as electrocatalytic interfacescitations
- 2016Identification of strain rate-dependent mechanical behaviour of DP600 under in-plane biaxial loadingscitations
- 2016Copolymerization of zinc-activated isoindigo- and naphthalene-diimide based monomers: an efficient route to low bandgap π-conjugated random copolymers with tunable properties
- 2016Strain Rate Dependent Hardening of DP600 Sheet Metal for Large Strains Under In-plane Biaxial Loadingscitations
- 2015Noble Metal Aerogels - Synthesis, Characterization, and Application as Electrocatalysts
- 2005[A case-control study on the mxA polymorphisms and susceptibility to severe acute respiratory syndromes].
- 2003[A case-control study on natural-resistance-associated macrophage protein 1 gene polymorphisms and susceptibility to pulmonary tuberculosis].
Places of action
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article
Stealth Biocompatible Si-Based Nanoparticles for Biomedical Applications
Abstract
A challenge regarding the design of nanocarriers for drug delivery is to prevent their recognition by the immune system. To improve the blood residence time and prevent their capture by organs, nanoparticles can be designed with stealth properties using polymeric coating. In this study, we focused on the influence of surface modification with polyethylene glycol and/or mannose on the stealth behavior of porous silicon nanoparticles (pSiNP, similar to 200 nm). In vivo biodistribution of pSiNPs formulations were evaluated in mice 5 h after intravenous injection. Results indicated that the distribution in the organs was surface functionalization-dependent. Pristine pSiNPs and PEGylated pSiNPs were distributed mainly in the liver and spleen, while mannose-functionalized pSiNPs escaped capture by the spleen, and had higher blood retention. The most efficient stealth behavior was observed with PEGylated pSiNPs anchored with mannose that were the most excreted in urine at 5 h. The biodegradation kinetics evaluated in vitro were in agreement with these in vivo observations. The biocompatibility of the pristine and functionalized pSiNPs was confirmed in vitro on human cell lines and in vivo by cytotoxic and systemic inflammation investigations, respectively. With their biocompatibility, biodegradability, and stealth properties, the pSiNPs functionalized with mannose and PEG show promising potential for biomedical applications.