| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kumar, Sunil
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2024SMART-SLE: serology monitoring and repeat testing in systemic lupus erythematosus—an analysis of anti-double-stranded DNA monitoringcitations
- 2023Carbon-fibre-reinforced-PEEK and silicon doped amorphous carbon as a potential tribopair for implant applicationcitations
- 2023Comparative evaluation of dithranol-loaded nanosponges fabricated by solvent evaporation technique and melt methodcitations
- 2023Electrohydrodynamic capillary instability of Rivlin–Ericksen viscoelastic fluid film with mass and heat transfercitations
- 2022Formulation, Characterization, Anti-Inflammatory and Cytotoxicity Study of Sesamol-Laden Nanospongescitations
- 2021Recop: Fine-grained Opinions and Collaborative Filtering based Recommender System for Industry 5.0citations
- 2021Single-shot phase contrast microscopy using polarisation-resolved differential phase contrast
- 2020Increase in energy efficiency of a steel billet reheating furnace by heat balance study and process improvementcitations
- 2017Visible thermochromism in vanadium pentoxide coatingscitations
- 2016Effect of uniformly applied force and molecular characteristics of a polymer chain on its adhesion to graphene substratescitations
- 2016Electrical Switching in Semiconductor-Metal Self-Assembled VO2 Disordered Metamaterial Coatingscitations
- 2011Influence of hydrogen content on impact toughness of Zr-2.5Nb pressure tube alloycitations
- 2010Terahertz Spectroscopy of Single-Walled Carbon Nanotubes in a Polymer Film: Observation of Low-Frequency Phononscitations
- 2010Friction, wear and surface characterization of metal-on-metal implant in protein rich lubrications
Places of action
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article
Formulation, Characterization, Anti-Inflammatory and Cytotoxicity Study of Sesamol-Laden Nanosponges
Abstract
<jats:p>Sesamol (SES) possesses remarkable chemotherapeutic activity, owing to its anti-inflammatory and antioxidant potential. However, the activity of SES is mainly hampered by its poor physicochemical properties and stability issues. Hence, to improve the efficacy of this natural anti-inflammatory and cytotoxic agent, it was loaded into β-cyclodextrin nanosponges (NS) prepared using different molar ratios of polymer and crosslinker (diphenyl carbonate). The particle size of SES-laden NS (SES-NS) was shown to be in the nano range (200 to 500 nm), with a low polydispersity index, an adequate charge (−17 to −26 mV), and a high payload. Field emission scanning electron microscopy, thermogravimetric analysis, and Fourier transform infrared spectroscopy were used to characterize the bioactive-loaded selected batch (SES-NS6). This batch of nanoformulations showed improved solubilization efficacy (701.88 µg/mL) in comparison to bare SES (244.36 µg/mL), polymer (β-CD) (261.43 µg/mL), and other fabricated batches. The drug release data displayed the controlled release behavior of SES from NS. The findings of the egg albumin denaturation assay revealed the enhanced anti-inflammatory potential of SES-NS as compared to bare SES. Further, the cytotoxicity assay showed that SES-NS was more effective against B16F12 melanoma cell lines than the bioactive alone. The findings of this assay demonstrated a reduction in the IC50 values of SES-NS (67.38 μg/mL) in comparison to SES (106 μg/mL). The present investigation demonstrated the in vitro controlled release pattern and the enhanced anti-inflammatory and cytotoxic activity of SES-NS, suggesting its potential as a promising drug delivery carrier for topical delivery.</jats:p>