| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Chiellini, Federica
University of Pisa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (26/26 displayed)
- 2022Smart Magnetic Nanocarriers for Multi-Stimuli On-Demand Drug Deliverycitations
- 2022Development and characterization of highly stable silver nanoparticles as novel potential antimicrobial agents for wound healing hydrogelscitations
- 2020Mono-, Di- and Tetra-iron Complexes with Selenium or Sulphur Functionalized Vinyliminium Ligands: Synthesis, Structural Characterization and Antiproliferative Activitycitations
- 2019Biomedical processing of polyhydroxyalkanoatescitations
- 2018Biofabrication via integrated additive manufacturing and electrofluidodynamicscitations
- 2017Additive manufacturing of poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] scaffolds for engineered bone developmentcitations
- 2017Additive Manufacturing of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/poly(ε-caprolactone) Blend Scaffolds for Tissue Engineeringcitations
- 2016Microstructured chitosan/poly(γ-glutamic acid) polyelectrolyte complex hydrogels by computer-aided wet-spinning for biomedical three-dimensional scaffoldscitations
- 2015Additive manufacturing techniques for the production of tissue engineering constructscitations
- 2014Preparation and characterization of biodegradable amphiphilic polymers and nanoparticles with high protein-loading capacitycitations
- 2013A new hydroxyapatite-based biocomposite for bone replacementcitations
- 2013Multiblock Copolymers of e–Caprolactone and Ethylene Glycol Containing Periodic Side-Chain Carboxyl Groups: Synthesis, Characterization, and Nanoparticle Preparationcitations
- 2012Synthesis and characterization of semi-interpenetrating polymer network hydrogel based on chitosan and poly(methacryloylglycylglycine)citations
- 2012Chalcone embedded polyurethanes as a biomaterial: Synthesis, characterization and antibacterial adhesion
- 2011Polymeric nanostructured items electrospun on a cylindrical template: A simple procedure for their removalcitations
- 2010Production of Bioglass® 45S5 - Polycaprolactone composite scaffolds via salt-leachingcitations
- 2010Novel electrospun polyurethane/gelatin composite meshes for vascular graftscitations
- 2010Preparation of stable dispersion of barium titanate nanoparticles: Potential applications in biomedicinecitations
- 2010Highly porous polycaprolactone-45s5 bioglass scaffolds for bone tissue engineeringcitations
- 2010Polymeric Materials for Bone and Cartilage Repaircitations
- 2009DI-(2-ETHYLHEXYL)PHTHALATE LEAKAGE AND COLOR CHANGES IN ENDOTRACHEAL TUBES AFTER APPLICATION IN HIGH-RISK NEWBORNScitations
- 2008Development of a bioactive glass fiber reinforced starch-polycaprolactone compositecitations
- 2008Di-(2-ethylhexyl)phthalate Leakage and Color Changes in Endotracheal Tubes after Application in High-Risk Newbornscitations
- 2008A New Biocompatible Nanoparticle Delivery System for the Release of Fibrinolytic Drugscitations
- 2006Bioerodible polymeric nanoparticles for targeted delivery of proteic drugscitations
- 2001Patterning of Polymeric Hydrogels for Biomedical Applications
Places of action
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article
Smart Magnetic Nanocarriers for Multi-Stimuli On-Demand Drug Delivery
Abstract
<jats:p>In this study, we report the realization of drug-loaded smart magnetic nanocarriers constituted by superparamagnetic iron oxide nanoparticles encapsulated in a dual pH- and temperature-responsive poly (N-vinylcaprolactam-co-acrylic acid) copolymer to achieve highly controlled drug release and localized magnetic hyperthermia. The magnetic core was constituted by flower-like magnetite nanoparticles with a size of 16.4 nm prepared by the polyol approach, with good saturation magnetization and a high specific absorption rate. The core was encapsulated in poly (N-vinylcaprolactam-co-acrylic acid) obtaining magnetic nanocarriers that revealed reversible hydration/dehydration transition at the acidic condition and/or at temperatures above physiological body temperature, which can be triggered by magnetic hyperthermia. The efficacy of the system was proved by loading doxorubicin with very high encapsulation efficiency (>96.0%) at neutral pH. The double pH- and temperature-responsive nature of the magnetic nanocarriers facilitated a burst, almost complete release of the drug at acidic pH under hyperthermia conditions, while a negligible amount of doxorubicin was released at physiological body temperature at neutral pH, confirming that in addition to pH variation, drug release can be improved by hyperthermia treatment. These results suggest this multi-stimuli-sensitive nanoplatform is a promising candidate for remote-controlled drug release in combination with magnetic hyperthermia for cancer treatment.</jats:p>