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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Balcells, Lluis
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Tuning the superconducting performance of YBa2Cu3O7-δ films through field-induced oxygen dopingcitations
- 2023Spin-to-Charge Conversion in All-Oxide La2/3Sr1/3MnO3/SrIrO3 Heterostructurescitations
- 2023Impact of Twin's Landscape on the Magnetic Damping of La2/3Sr1/3MnO3 Thin Films
- 2022Spin to charge conversion in chemically deposited epitaxial La0.9MnO3 thin films capped with Ptcitations
- 2022Optimization of the Growth Process of Double Perovskite Pr2−δNi1−xMn1+xO6−y Epitaxial Thin Films by RF Sputteringcitations
- 2022X-ray Absorption Spectroscopy Study of Thickness Effects on the Structural and Magnetic Properties of Pr2-δNi1-xMn1+xO6-y Double Perovskite Thin Filmscitations
- 2021Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapycitations
- 2021Critical magnetic behavior in [Ag8/Co0.5]x64, [Ag8/Co1]x32 and [Ag16/Co1]x32 epitaxial multilayers
- 2021Fractal polymer islands on top of ferromagnetic La2Ni0.6Mn1.4O6 thin films
- 2021Formation of Nickel Oxide Nanocuboids in Ferromagnetic La2Ni1−xMn1+xO6
- 2019Nonstoichiometry Driven Ferromagnetism in Double Perovskite La2Ni1−xMn1+xO6 Insulating Thin Films
- 2019Low temperature superspin glass behavior in a Co/Ag multilayercitations
- 2016Strain-induced perpendicular magnetic anisotropy in La2CoMnO6−ε thin films and its dependence on film thicknesscitations
- 2016Isothermal anisotropic magnetoresistance in antiferromagnetic metallic IrMncitations
- 2011Thermal, dielectrical and mechanical response of alpha and beta-poly(vynilidene fluoride)/Co-MgO nanocompositescitations
Places of action
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article
Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy
Abstract
<jats:p>A magnetic nanocomposite, consisting of Fe3O4 nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequential hydrolysis of iron salts (Fe2+, Fe3+) and Mg2+/Al3+ nitrates in a carbonate-rich mild alkaline environment followed by the loading of 5-fluorouracil, an anionic anticancer drug, in the interlayer LDH space. Magnetite nanoparticles with a diameter around 30 nm, dispersed in water, constitute the hyperthermia-active phase able to generate a specific loss of power of around 500 W/g-Fe in an alternating current (AC) magnetic field of 24 kA/m and 300 kHz as determined by AC magnetometry and calorimetric measurements. Heat transfer was found to trigger a very rapid release of drug which reached 80% of the loaded mass within 10 min exposure to the applied field. The potential of the Fe3O4/LDH nanocomposites as cancer treatment agents with minimum side-effects, owing to the exclusive presence of inorganic phases, was validated by cell internalization and toxicity assays.</jats:p>