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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kubicki, Maciej
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (20/20 displayed)
- 2024In vitro anticancer, antioxidant, antimicrobial, antileishmanial, enzymes inhibition and in vivo anti-inflammatory activities of organotin(IV) derivatives of 4-bromophenoxyacetic acidcitations
- 2024Self-assembly of simple Schiff base ligand into unique saddle-type [4x4] tetranuclear architecture and its application as selective voltammetric dopamine sensor in aqueous conditionscitations
- 2023New N4-Donor Ligands as Supramolecular Guests for DNA and RNA: Synthesis, Structural Characterization, In Silico, Spectrophotometric and Antimicrobial Studiescitations
- 2021Electropolymerization of [2 × 2] grid-type cobalt(II) complex with thiophene substituted dihydrazone ligandcitations
- 2019Complexation behavior of 6,6″-dimethyl-2,2′:6′,2″-terpyridine ligand with Co(II), Au(III), Ag(I), Zn(II) and Cd(II) ions: Synthesis, spectroscopic characterization and unusual structural motifscitations
- 2019Solid-state supramolecular architectures of a series of Hg(II) halide coordination compounds based on hydroxyl-substituted Schiff base ligandscitations
- 2018Coordination properties of N,N′-bis(5-methylsalicylidene)-2-hydroxy-1,3-propanediamine with d- and f-electron ions: crystal structure, stability in solution, spectroscopic and spectroelectrochemical studiescitations
- 2018Co(III), V(IV) and Cu(II) complexes of bidentate N,O-donor Schiff base ligands: Characterization, anticancer activities and metal oxide nanoparticles preparation via solid state thermal decompositioncitations
- 2018Synthesis, X-ray crystallography, thermogravimetric analysis and spectroscopic characterization of isostructural one-dimensional coordination polymers as sorbents for some anionscitations
- 2018Recurrent supramolecular motifs in discrete complexes and coordination polymers based on mercury halides: prevalence of chelate ring stacking and substituent effectscitations
- 2017A mechanistic study on unexpected and solvent-based pH-tuneable role of benzylic pendant side-arm on N2O2-donor naphthodiaza-crown macrocyclic ligand as a sensitive fluorogenic chemosensor for Al3+ in aqueous solutioncitations
- 2017Dipyrromethane functionalized monomers as precursors of electrochromic polymerscitations
- 2017The spectroscopic studies of new polymeric complexes of silver(I) and original mononuclear complexes of lanthanides(III) with benzimidazole-based hydrazonecitations
- 2016Utilization of a new gold/Schiff-base iron(iii) complex composite as a highly sensitive voltammetric sensor for determination of epinephrine in the presence of ascorbic acidcitations
- 2015Two types of lanthanide Schiff base complexes: Synthesis, structure and spectroscopic studiescitations
- 2015Different supramolecular architectures in self-assembled praseodymium(III) and europium(III) complexes with rare coordination pattern of salicylaldimine ligandcitations
- 2015Supramolecular polymer of Schiff base gadolinium complex: Synthesis, crystal structure and spectroscopic propertiescitations
- 2013New complexes of cobalt(II) ions with pyridinecarboxylic acid N-oxides and 4,4′-bypcitations
- 2013Mono-, di- and trinuclear complexes of bis(terpyridine) ligand: Synthesis, crystal structures and magnetic propertiescitations
- 2012Synthesis, complexation studies and structural characterization of d and f metal ion complexes with 4-chloroquinaldinic acid N-oxidecitations
Places of action
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article
New N4-Donor Ligands as Supramolecular Guests for DNA and RNA: Synthesis, Structural Characterization, In Silico, Spectrophotometric and Antimicrobial Studies
Abstract
<jats:p>The present work reports the synthesis of new N4-donor compounds carrying p-xylyl spacers in their structure. Different Schiff base aliphatic N-donors were obtained synthetically and subsequently evaluated for their ability to interact with two models of nucleic acids: calf-thymus DNA (CT-DNA) and the RNA from yeast Saccharomyces cerevisiae (herein simply indicated as RNA). In more detail, by condensing p-xylylenediamine and a series of aldehydes, we obtained the following Schiff base ligands: 2-thiazolecarboxaldehyde (L1), pyridine-2-carboxaldehyde (L2), 5-methylisoxazole-3-carboxaldehyde (L3), 1-methyl-2-imidazolecarboxaldehyde (L4), and quinoline-2-carboxaldehyde (L5). The structural characterisation of the ligands L1-L5 (X-ray, 1H NMR, 13C NMR, elemental analysis) and of the coordination polymers {[CuL1]PF6}n (herein referred to as Polymer1) and {[AgL1]BF4}n, (herein referred to as Polymer2, X-ray, 1H NMR, ESI-MS) is herein described in detail. The single crystal X-ray structures of complexes Polymer1 and Polymer2 were also investigated, leading to the description of one-dimensional coordination polymers. The spectroscopic and in silico evaluation of the most promising compounds as DNA and RNA binders, as well as the study of the influence of the 1D supramolecular polymers Polymer1 and Polymer2 on the proliferation of Escherichia coli bacteria, were performed in view of their nucleic acid-modulating and antimicrobial applications. Spectroscopic measurements (UV–Vis) combined with molecular docking calculations suggest that the thiazolecarboxaldehyde derivative L1 is able to bind CT-DNA with a mechanism different from intercalation involving the thiazole ring in the molecular recognition and shows a binding affinity with DNA higher than RNA. Finally, Polymer2 was shown to slow down the proliferation of bacteria much more effectively than the free Ag(I) salt.</jats:p>