| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Irfan, Muhammad
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2024Oxidized alginate-gelatin (ADA-GEL)/silk fibroin/Cu-Ag doped mesoporous bioactive glass nanoparticle-based hydrogels for potential wound care treatmentscitations
- 2024Utilization of NiO-rGO Nanoarchitectures-Based Composite Electrodes for High-Performance Electrochemical Applications
- 2023Harnessing the Antimicrobial Potential of Natural Starch and Mint Extract in PVA-Based Biodegradable films against Staphylococcus aureus bacteriacitations
- 2023Indoor water splitting for hydrogen production through electrocatalysis using composite metal oxide catalystscitations
- 2023Microencapsulation based fire retardant eco-friendly jute compositecitations
- 2023Temperature-Properties Relationships of Martensitic Stainless Steel for Improved Utilization in Surgical Tools
- 2022Zn–Mn-Doped Mesoporous Bioactive Glass Nanoparticle-Loaded Zein Coatings for Bioactive and Antibacterial Orthopedic Implantscitations
- 2022Assessing the Synergistic Activity of Clarithromycin and Therapeutic Oils Encapsulated in Sodium Alginate Based Floating Microbeadscitations
- 2022Electrospun Networks of ZnO-SnO2 Composite Nanowires as Electron Transport Materials for Perovskite Solar Cellscitations
- 2021Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterizationcitations
- 2021<i>Moringa oleifera</i> gum based silver and zinc oxide nanoparticles: green synthesis, characterization and their antibacterial potential against MRSAcitations
- 2018Comparative Experimental Study of Tribo-Mechanical Performance of Low-Temperature PVD Based TiN Coated PRCL Systems for Diesel Enginecitations
- 2018Fast photocatalytic degradation of dyes using low-power laser-fabricated Cu2O–Cu nanocompositescitations
- 2017Characterization of antibacterial silver nanocluster/silica composite coating on high performance Kevlar® textilecitations
- 2015Bisphenol A based polyester binder as an effective interlaminar toughenercitations
- 2012Lateral spreading of a fiber bundle via mechanical meanscitations
Places of action
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article
Assessing the Synergistic Activity of Clarithromycin and Therapeutic Oils Encapsulated in Sodium Alginate Based Floating Microbeads
Abstract
<jats:p>We developed alginate-based floating microbeads of clarithromycin with therapeutic oils for the possible eradication of Helicobacter pylori (H. pylori) infections by enhancing the residence time of the carrier at the site of infection. In pursuit of this endeavor, the alginate was blended with hydroxy propyl methyl cellulose (HPMC) as an interpenetrating polymer to develop beads by ionotropic gelation using calcium carbonate as a gas generating agent. The developed microbeads remained buoyant under gastric conditions for 24 h. These microbeads initially swelled and afterwards decreased in size, possibly due to the erosion of the polymer. Furthermore, swelling was also affected by the type of encapsulated oil, i.e., swelling decreased with increasing concentrations of eucalyptus oil and increased with increasing concentrations of oleic acid. Antibacterial assays of the formulations showed significant antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli); these assays also showed synergistic activity between clarithromycin and therapeutic oils as evident from the higher zone of inhibition of the microbeads as compared to the pure drug and oils. Scanning electron microscopy (SEM) images revealed a smoother surface for oleic acid containing the formulation as compared to eucalyptus oil containing the formulation. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) revealed the development of a stable formulation, while Fourier transform infrared spectrophotometry (FTIR) studies did not reveal any interaction between the polymers and the active ingredients. Optimized formulations (CLM3 and CLM6) were designed to release the drug in a controlled manner in gastric media by Fickian diffusion. Conclusively, the developed microbeads are a promising carrier to overcome the narrow therapeutic index and low bioavailability of clarithromycin, while the presence of therapeutic oils will produce synergistic effects with the drug to eradicate infection effectively.</jats:p>