| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Meyer, Anne S.
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2023Structural Characterization and Cytotoxic Activity Evaluation of Ulvan Polysaccharides Extracted from the Green Algae Ulva papenfussiicitations
- 2023Structural and functional characterization of the novel endo-α(1,4)-fucoidanase Mef1 from the marine bacterium Muricauda eckloniaecitations
- 2022Influence of substrate crystallinity and glass transition temperature on enzymatic degradation of polyethylene terephthalate (PET)citations
- 2022The Endo-α(1,3)-Fucoidanase Mef2 Releases Uniquely Branched Oligosaccharides from Saccharina latissima Fucoidanscitations
- 2022A new FTIR assay for quantitative measurement of endo-fucoidanase activitycitations
- 2021Biocompatible Graphene Oxide Nanosheets Densely Functionalized with Biologically Active Molecules for Biosensing Applicationscitations
- 2020Bioproduced Polymers Self-Assemble with Graphene Oxide into Nanocomposite Films with Enhanced Mechanical Performancecitations
- 2019Laccase activity measurement by FTIR spectral fingerprintingcitations
- 2017Targeted pre-treatment of hemp bast fibres for optimal performance in biocomposite materials: a reviewcitations
- 2017Rheological properties of agar and carrageenan from Ghanaian red seaweedscitations
- 2017Elemental analysis of various biomass solid fractions in biorefineries by X-ray fluorescence spectrometrycitations
- 2017Characterisation of Authentic Lignin Biorefinery Samples by Fourier Transform Infrared Spectroscopy and Determination of the Chemical Formula for Lignincitations
- 2017Prediction of Pectin Yield and Quality by FTIR and Carbohydrate Microarray Analysiscitations
Places of action
| Organizations | Location | People |
|---|
article
Structural Characterization and Cytotoxic Activity Evaluation of Ulvan Polysaccharides Extracted from the Green Algae Ulva papenfussii
Abstract
Ulvan, a sulfated heteropolysaccharide with structural and functional properties of interest for various uses, was extracted from the green seaweed <i>Ulva papenfussii</i>. <i>U. papenfussii</i> is an unexplored <i>Ulva</i> species found in the South China Sea along the central coast of Vietnam. Based on dry weight, the ulvan yield was ~15% (<i>w</i>/<i>w</i>) and the ulvan had a sulfate content of 13.4 wt%. The compositional constitution encompassed L-Rhamnose (Rha<i>p</i>), D-Xylose (Xyl<i>p</i>), D-Glucuronic acid (GlcA<i>p</i>), L-Iduronic acid (IdoA<i>p</i>), D-Galactose (Gal<i>p</i>), and D-Glucose (Glc<i>p</i>) with a molar ratio of 1:0.19:0.35:0.52:0.05:0.11, respectively. The structure of ulvan was determined using High-Performance Liquid Chromatography (HPLC), Fourier Transform Infrared Spectroscopy (FT-IR), and Nuclear Magnetic Resonance spectroscopy (NMR) methods. The results showed that the extracted ulvan comprised a mixture of two different structural forms, namely ("A3s") with the repeating disaccharide [→4)-β-D-GlcAp-(1→4)-α-L-Rhap 3S-(1→]n, and ("B3s") with the repeating disaccharide [→4)-α-L-IdoAp-(1→4)-α-L-Rhap 3S(1→]n. The relative abundance of A3s, and B3s was 1:1.5, respectively. The potential anticarcinogenic attributes of ulvan were evaluated against a trilogy of human cancer cell lineages. Concomitantly, Quantitative Structure-Activity Relationship (QSAR) modeling was also conducted to predict potential adverse reactions stemming from pharmacological interactions. The ulvan showed significant antitumor growth activity against hepatocellular carcinoma (IC<sub>50</sub> ≈ 90 µg/mL), human breast cancer cells (IC<sub>50</sub> ≈ 85 µg/mL), and cervical cancer cells (IC<sub>50</sub> ≈ 67 µg/mL). The QSAR models demonstrated acceptable predictive power, and seven toxicity indications confirmed the safety of ulvan, warranting its candidacy for further in vivo testing and applications as a biologically active pharmaceutical source for human disease treatment.