| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Manzoli, Maela
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2024Physicochemical properties and redox behaviour of Fe-doped hybrid nanotubes of the imogolite type and their rGO nanocompositescitations
- 2024Mechanochemical Preparation of New Biocomposites Starting from Polymers and Plant-Derived Fibres
- 2023Freeze Drying of Polymer Nanoparticles and Liposomes Exploiting Different Saccharide-Based Approachescitations
- 2021New Insights in the Production of Simulated Moon Agglutinates: the Use of Natural Zeolite-Bearing Rockscitations
- 2020DFT-assisted spectroscopic studies on the coordination of small ligands to palladium: from isolated ions to nanoparticlescitations
- 2018Magnetic metal-ceramic nanocomposites obtained from cation-exchanged zeolite by heat treatment in reducing atmospherecitations
- 2017CO2 Hydrogenation over Pt-Containing UiO-67 Zr-MOFs—The Base Casecitations
- 2016Characterisation of gold catalystscitations
- 2013Investigation on the Stability of Supported Gold Nanoparticlescitations
- 2013Investigating site-specific interactions and probing their role in modifying the acid-strength in framework architecturescitations
- 2012Supported Ni catalysts prepared by intercalation of layered double hydroxides: investigation of acid-base properties and nature of Ni phasescitations
- 2006Catalysis and photocatalysis on nanostructured materials based on titania
- 2004Pd/Mg(Al)O catalysts obtained from Hydrotalcites: investigation of acid-base properties and nature of Pd phasescitations
Places of action
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article
Freeze Drying of Polymer Nanoparticles and Liposomes Exploiting Different Saccharide-Based Approaches
Abstract
Biodegradable nanocarriers represent promising tools for controlled drug delivery. However, one major drawback related to their use is the long-term stability, which is largely influenced by the presence of water in the formulations, so to solve this problem, freeze-drying with cryoprotectants has been proposed. In the present study, the influence of the freeze-drying procedure on the storage stability of poly(lactide-co-glycolide) (PLGA) nanoparticles and liposomes was evaluated. In particular, conventional cryoprotectants were added to PLGA nanoparticle and liposome formulations in various conditions. Additionally, hyaluronic acid (HA), known for its ability to target the CD44 receptor, was assessed as a cryoprotective excipient: it was added to the nanocarriers as either a free molecule or conjugated to a phospholipid to increase the interaction with the polymer or lipid matrix while exposing HA on the nanocarrier surface. The formulations were resuspended and characterized for size, polydispersity index, zeta potential and morphology. It was demonstrated that only the highest percentages of cryoprotectants allowed the resuspension of stable nanocarriers. Moreover, unlike free HA, HA-phospholipid conjugates were able to maintain the particle mean size after the reconstitution of lyophilized nanoparticles and liposomes. This study paves the way for the use of HA-phospholipids to achieve, at the same time, nanocarrier cryoprotection and active targeting.