| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Gallego-Ferrer, Gloria
Universitat Politècnica de València
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2023Copper–zinc/chitosan complex hydrogels: Rheological, degradation and biological propertiescitations
- 2022Metal Ion Doping of Alginate-Based Surface Coatings Induces Adipogenesis of Stem Cellscitations
- 2021PCL-Coated Multi-Substituted Calcium Phosphate Bone Scaffolds with Enhanced Propertiescitations
- 2021Biomimetic 3D Environment Based on Microgels as a Model for the Generation of Drug Resistance in Multiple Myelomacitations
- 2019Freeze-extraction microporous electroactive supports for cell culturecitations
- 2018Injectable chitosan-hydroxyapatite hydrogels promote the osteogenic differentiation of mesenchymal stem cellscitations
- 2017Emulsion based microencapsulation of proteins in poly(L-lactic acid) films and membranes for the controlled release of drugscitations
- 2016Role of chemical crosslinking in material-driven assembly offibronectin (nano)networks: 2D surfaces and 3D scaffoldscitations
- 2016In Situ Hydroxyapatite Content Affects the Cell Differentiation on Porous Chitosan/Hydroxyapatite Scaffoldscitations
- 2016Prediction of the in vivo mechanical behavior of biointegrable acrylic macroporous scaffoldscitations
- 2015Bioactive organic inorganic poly(CLMA-co-HEA)/silica nanocompositescitations
- 2014PCL-coated hydroxyapatite scaffold derived from cuttlefish bone: Morphology, mechanical properties and bioactivitycitations
Places of action
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article
PCL-Coated Multi-Substituted Calcium Phosphate Bone Scaffolds with Enhanced Properties
Abstract
<jats:p>Ionic substitutions within the hydroxyapatite lattice are a widely used approach to mimic the chemical composition of the bone mineral. In this work, Sr-substituted and Mg- and Sr-co-substituted calcium phosphate (CaP) scaffolds, with various levels of strontium and magnesium substitution, were prepared using the hydrothermal method at 200 °C. Calcium carbonate skeletons of cuttlefish bone, ammonium dihydrogenphosphate (NH4H2PO4), strontium nitrate (Sr(NO3)2), and magnesium perchlorate (Mg(ClO4)2) were used as reagents. Materials were characterized by means of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Whole powder pattern decomposition refinements of XRD data indicated that increased magnesium content in the Mg- and Sr-co-substituted scaffolds was related to an increased proportion of the whitlockite (WH) phase in the biphasic hydroxyapatite (HAp)/WH scaffolds. In addition, refinements indicate that Sr2+ ions have replaced Ca2+ sites in the WH phase. Furthermore, PCL-coated Mg-substituted and Sr- and Mg-co-substituted scaffolds, with the HAp:WH wt. ratio of 90:10 were prepared by vacuum impregnation. Results of compression tests showed a positive impact of the WH phase and PCL coating on the mechanical properties of scaffolds. Human mesenchymal stem cells (hMSCs) were cultured on composite scaffolds in an osteogenic medium for 21 days. Immunohistochemical staining showed that Mg-Sr-CaP/PCL scaffold exhibited higher expression of collagen type I than the Mg-CaP/PCL scaffold, indicating the positive effect of Sr2+ ions on the differentiation of hMSCs, in concordance with histology results. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis confirmed an early stage of osteogenic differentiation.</jats:p>