| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Raducka, Anita
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2022Design, Synthesis, and Characterization of Novel Coordination Compounds of Benzimidazole Derivatives with Cadmiumcitations
- 2022In Silico ADME and Toxicity Prediction of Benzimidazole Derivatives and Its Cobalt Coordination Compounds. Synthesis, Characterization and Crystal Structurecitations
- 2021Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancercitations
- 2021Cytotoxic Activity against A549 Human Lung Cancer Cells and ADMET Analysis of New Pyrazole Derivativescitations
- 2021Influence of Incorporation of Different dn-Electron Metal Cations into Biologically Active System on Its Biological and Physicochemical Propertiescitations
- 2019Crystal structure and thermoanalytical study of neodymium(III) complex with 2,4'-bipyridyne
Places of action
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article
Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer
Abstract
Four new ligands and four new copper (II) coordination compounds were prepared andcharacterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transforminfrared spectroscopy). The nature of metal–ligand coordination was investigated. The thermalproperties of complexes in the solid state were studied using TG-MS techniques (thermogravimetricanalysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis.The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metaboliccells as an IC50 (half maximal inhibitory concentration). The relationship between antitumor activityand the position of nitrogen atoms in the organic ligand has been shown.