| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bednarcik, Jozef
Slovak Academy of Sciences
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (33/33 displayed)
- 2023Maximizing vitrification and density of a Zr-based glass-forming alloy processed by laser powder bed fusioncitations
- 2022Fe0.79Si0.07B0.14 metallic glass gaskets for high-pressure research beyond 1 Mbarcitations
- 2022A role of atomic size misfit in lattice distortion and solid solution strengthening of TiNbHfTaZr high entropy alloy systemcitations
- 2021Fe$_{0.79}$Si$_{0.07}$B$_{0.14}$ metallic glass gaskets for high-pressure research beyond 1 Mbar
- 2021Compositional complexity dependence of lattice distortion in FeNiCoCrMn high entropy alloy systemcitations
- 2021Thermosensitive Drug Delivery System SBA-15-PEI for Controlled Release of Nonsteroidal Anti-Inflammatory Drug Diclofenac Sodium Salt: A Comparative Studycitations
- 2020Compositional complexity dependence of dislocation density and mechanical properties in high entropy alloy systemscitations
- 2020In situ XRD Study of Rapid Crystallization of Metallic Glasses Using Novel Experimental Setup for Flash-Annealing
- 2020Electronic structure based design of thin film metallic glasses with superior fracture toughnesscitations
- 2020Fast-current-heating devices to study in situ phase formation in metallic glasses by using high-energy synchrotron radiationcitations
- 2019Key Factor for the Transformation from hcp to 18R-Type Long-Period Stacking Ordered Structure in Mg Alloyscitations
- 2019A mechanochemical route for the synthesis of $VNbO_{5}$ and its structural re-investigation using structure solution from powder diffraction datacitations
- 2019A comparison study of dislocation density, recrystallization and grain growth among nickel, FeNiCo ternary alloy and FeNiCoCrMn high entropy alloycitations
- 2019Anomalous behavior of thermal expansion of α-Fe impurities in the $La(Fe,Co,Si)_{13-}$ based alloys modified by Mn or selected lanthanides (Ce, Pr, Ho)citations
- 2018Nano-laminated thin film metallic glass design for outstanding mechanical propertiescitations
- 2018Structural, microstructural and magnetic evolution in cryo milled carbon doped MnAlcitations
- 2017Synthesis, structures and thermal decomposition of ammine MxB12H12 complexes (M = Li, Na, Ca)citations
- 2017Synthesis, structures and thermal decomposition of ammine M x B 12 H 12 complexes (M = Li, Na, Ca)citations
- 2017Ultra-stiff metallic glasses through bond energy density designcitations
- 2017Synthesis, structures and thermal decomposition of ammine $mathrm{M_{x}B_{12}H_{12}}$ complexes (M = Li, Na, Ca)citations
- 2017Insights into formation and stability of $mathrm{tau-MnAlZ_{x}}$ (Z = C and B)citations
- 2017Insights into formation and stability of τ-MnAlZx (Z = C and B)citations
- 2016Synthesis of $Al_{2}O_{3}/SiO_{2}$ Nano-Nano Composite Ceramics under High Pressure and Its Inverse Hall-Petch Behaviorcitations
- 2016Revealing the relationships between chemistry, topology and stiffness of ultrastrong Co-based metallic glass thin films: A combinatorial approachcitations
- 2015Strain Mapping of Indented Zr-Based Bulk Metallic Glass Using Nano-Diffraction
- 2015Linking Structure to Fragility in Bulk Metallic Glass-Forming Liquidscitations
- 2015Synchronized Collapse and Formation of Long-Period Stacking and Chemical Orders in $mathrm{Mg_{85}Zn_6Y_9}$citations
- 2014Temperature-Induced Short-Range Order Changes in $Co_{67}B_{33}$ Glassy Thin Films and Elastic Limit Implicationscitations
- 2014Magnetic nanocomposites of periodic mesoporous silica: The influence of the silica substrate dimensionality on the inter-particle magnetic interactionscitations
- 2014Local atomic and crystal structure rearrangement during the martensitic transformation in $Ti_{5}0Ni_{25}Cu_{25}$ shape memory alloycitations
- 2013In situ XRD studies of nanocrystallization of Fe-based metallic glass: a comparative study by reciprocal and direct space methodscitations
- 2013Local crystal structure of TiNiCu shape memory alloyscitations
- 2013Structural behaviour of $Pd_{40}Cu_{30}Ni_{10}P_{20}$ metallic glass under high pressurecitations
Places of action
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article
Thermosensitive Drug Delivery System SBA-15-PEI for Controlled Release of Nonsteroidal Anti-Inflammatory Drug Diclofenac Sodium Salt: A Comparative Study
Abstract
<jats:p>Mesoporous SBA-15 silica material was prepared by the sol–gel method and functionalized with thermosensitive polyethylenimine polymers with different molecular weight (g·mol−1): 800 (SBA-15(C)-800), 1300 (SBA-15(C)-1300) and 2000 (SBA-15(C)-2000). The nonsteroidal anti-inflammatory drug (NSAID) diclofenac sodium was selected as a model drug and encapsulated into the pores of prepared supports. Materials were characterized by the combination of infrared spectroscopy (IR), atomic force microscopy (AFM), transmission electron microscopy (TEM), photon cross-correlation spectroscopy (PCCS), nitrogen adsorption/desorption analysis, thermogravimetry (TG), differential scanning calorimetry (DSC) and small-angle X-ray diffraction (SA-XRD) experiments. The drug release from prepared matrixes was realized in two model media differing in pH, namely small intestine environment/simulated body fluid (pH = 7.4) and simulated gastric fluid (pH = 2), and at different temperatures, namely normal body temperature (T = 37 °C) and inflammatory temperature (T = 42 °C). The process of drug loading into the pores of prepared materials from the diclofenac sodium salt solutions with different concentrations and subsequent quantitative determination of released drugs was analyzed by UV-VIS spectroscopy. Analysis of prepared SBA-15 materials modified with polyethylenimines in solution showed a high ability to store large amounts of the drug, up to 230 wt.%. Experimental results showed their high drug release into the solution at pH = 7.4 for both temperatures, which is related to the high solubility of diclofenac sodium in a slightly alkaline environment. At pH = 2, a difference in drug release rate was observed between both temperatures. Indeed, at a higher temperature, the release rates and the amount of released drug were 2–3 times higher than those observed at a lower temperature. Different kinetic models were used to fit the obtained drug release data to determine the drug release rate and its release mechanism. Moreover, the drug release properties of prepared compounds were compared to a commercially available medicament under the same experimental conditions.</jats:p>