| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rosenholm, Jessica M.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2023Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugscitations
- 2023Semi-solid 3D printing of mesoporous silica nanoparticle-incorporated xeno-free nanomaterial hydrogels for protein deliverycitations
- 2023Directing cellular responses in a nanocomposite 3D matrix for tissue regeneration with nanoparticle-mediated drug deliverycitations
- 2022Microfluidic-Assisted Fabrication of Dual-Coated pH-Sensitive Mesoporous Silica Nanoparticles for Protein Deliverycitations
- 2022Core@shell structured ceria@mesoporous silica nanoantibiotics restrain bacterial growth in vitro and in vivocitations
- 2021Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatmentcitations
- 2020Opportunities and Challenges of Silicon‐based Nanoparticles for Drug Delivery and Imagingcitations
- 2019Nanodiamond based complexes for prolonged dexamethasone releasecitations
- 2019Brilliant blue, green, yellow, and red fluorescent diamond particles: synthesis, characterization, and multiplex imaging demonstrationscitations
- 2018Monitoring of the excretion of fluorescent nanocomposites out of the body using artificial neural networkscitations
- 2018Neural Network Classification Method for Solution of the Problem of Monitoring Theremoval of the Theranostics Nanocomposites from an Organismcitations
- 2018A method for optical imaging and monitoring of the excretion of fluorescent nanocomposites from the body using artificial neural networkscitations
- 2013Core–shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery I: fabricationcitations
Places of action
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article
Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs
Abstract
A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70–90% of drug candidates in the development stage are poorly soluble, which results in low bioavailability, diminished therapeutic effects, and dosage escalation. Because of this, solubility must be taken into consideration when developing and fabricating pharmaceutical products. To date, a number of approaches have been investigated to address the problem of poor solubility. This review article attempts to summarize several conventional methods utilized to increase the solubility of poorly soluble drugs. These methods include the principles of physical and chemical approaches such as particle size reduction, solid dispersion, supercritical fluid technology, cryogenic technology, inclusion complex formation techniques, and floating granules. It includes structural modification (i.e., prodrug, salt formation, co-crystallization, use of co-solvents, hydrotrophy, polymorphs, amorphous solid dispersions, and pH variation). Various nanotechnological approaches such as liposomes, nanoparticles, dendrimers, micelles, metal organic frameworks, nanogels, nanoemulsions, nanosuspension, carbon nanotubes, and so forth have also been widely investigated for solubility enhancement. All these approaches have brought forward the enhancement of the bioavailability of orally administered drugs by improving the solubility of poorly water-soluble drugs. However, the solubility issues have not been completely resolved, owing to several challenges associated with current approaches, such as reproducibility in large scale production. Considering that there is no universal approach for solving solubility issues, more research is needed to simplify the existing technologies, which could increase the number of commercially available products employing these techniques.