Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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Materials Map under construction

The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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1.080 Topics available

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977 Locations available

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (3/3 displayed)

  • 2023Effects of Gamma Irradiation and Supercritical Carbon Dioxide Sterilization on Methacrylated Gelatin/Hyaluronan Hydrogels5citations
  • 2019Recapitulating bone development events in a customised bioreactor through interplay of oxygen tension, medium pH, and systematic differentiation approaches1citations
  • 2017Developing a Customized Perfusion Bioreactor Prototype with Controlled Positional Variability in Oxygen Partial Pressure for Bone and Cartilage Tissue Engineering20citations

Places of action

Chart of shared publication
Wiesmann, Hans-Peter
1 / 1 shared
Buchner, Frauke
1 / 1 shared
Kruppke, Benjamin
1 / 5 shared
Hintze, Vera
2 / 5 shared
Bernhardt, Anne
1 / 5 shared
Heinemann, Christiane
1 / 4 shared
Cuniberti, Gianaurelio
2 / 456 shared
Friedrichs, Jens
1 / 8 shared
Hess, Ricarda
2 / 2 shared
Haenchen, Vanessa
1 / 1 shared
Scharnweber, Dieter
2 / 8 shared
Eckert, Hagen
2 / 6 shared
Krawetz, Roman
2 / 2 shared
Gelinsky, Michael
2 / 35 shared
Rancourt, Derrick
2 / 2 shared
Chart of publication period
2023
2019
2017

Co-Authors (by relevance)

  • Wiesmann, Hans-Peter
  • Buchner, Frauke
  • Kruppke, Benjamin
  • Hintze, Vera
  • Bernhardt, Anne
  • Heinemann, Christiane
  • Cuniberti, Gianaurelio
  • Friedrichs, Jens
  • Hess, Ricarda
  • Haenchen, Vanessa
  • Scharnweber, Dieter
  • Eckert, Hagen
  • Krawetz, Roman
  • Gelinsky, Michael
  • Rancourt, Derrick
OrganizationsLocationPeople

article

Effects of Gamma Irradiation and Supercritical Carbon Dioxide Sterilization on Methacrylated Gelatin/Hyaluronan Hydrogels

  • Wiesmann, Hans-Peter
  • Buchner, Frauke
  • Kruppke, Benjamin
  • Lee, Poh Soo
  • Hintze, Vera
  • Bernhardt, Anne
  • Heinemann, Christiane
Abstract

<p>Biopolymer hydrogels have become an important group of biomaterials in experimental and clinical use. However, unlike metallic or mineral materials, they are quite sensitive to sterilization. The aim of this study was to compare the effects of gamma irradiation and supercritical carbon dioxide (scCO2) treatment on the physicochemical properties of different hyaluronan (HA)- and/or gelatin (GEL)-based hydrogels and the cellular response of human bone marrow-derived mesenchymal stem cells (hBMSC). Hydrogels were photo-polymerized from methacrylated HA, methacrylated GEL, or a mixture of GEL/HA. The composition and sterilization methods altered the dissolution behavior of the biopolymeric hydrogels. There were no significant differences in methacrylated GEL release but increased methacrylated HA degradation of gamma-irradiated samples. Pore size/form remained unchanged, while gamma irradiation decreased the elastic modulus from about 29 kPa to 19 kPa compared to aseptic samples. HBMSC proliferated and increased alkaline phosphatase activity (ALP) particularly in aseptic and gamma-irradiated methacrylated GEL/HA hydrogels alike, while scCO2 treatment had a negative effect on both proliferation and osteogenic differentiation. Thus, gamma-irradiated methacrylated GEL/HA hydrogels are a promising base for multi-component bone substitute materials.</p>

Topics
  • pore
  • mineral
  • Carbon
  • biomaterials