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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Grabchev, Ivo
Sofia University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2024New Iron(III)-Containing Composite of Salinomycinic Acid with Antitumor Activity—Synthesis and Characterizationcitations
- 2022Characterization of a fluorescent 1,8-naphthalimide-functionalized PAMAM dendrimer and its Cu(ii) complexes as cytotoxic drugs: EPR and biological studies in myeloid tumor cellscitations
- 2009A new colorimetric and fluorimetric sensor for metal cations based on poly(propilene amine) dendrimer modified with 1,8-naphthalimidecitations
- 2008First generation poly(propyleneimine) dendrimers functionalised with 1,8-naphthalimide units as fluorescence sensors for metal cations and protonscitations
- 2007Synthesis and spectral properties of new green fluorescent poly(propyleneimine) dendrimers modified with 1,8-naphthalimide as sensors for metal cationscitations
- 2007Photodegradation of poly (amidoamine) dendrimers peripherally modified with 1,8-naphthalimide unitscitations
- 2006Sensors for detecting metal ions and protons based on new green fluorescent poly (amidoamine) dendrimers peripherally modified with 1,8-naphthalimidescitations
- 2006Sensor activity, photodegradation and photostabilisation of a PAMAM dendrimer comprising 1,8-naphthalimide functional groups in its peripherycitations
- 2006Green fluorescence poly(amidoamine) dendrimer functionalized with 1,8-naphthalimide units as potential sensor for metal cationscitations
- 2004Poly(amidoamine) dendrimer peripherally modified with 4-N,N-dimethylaminoethyleneamino-1,8-naphthalimide as a sensor of metal cations and protonscitations
- 2003A polyamidoamine dendrimer with peripheral 1,8-naphthalimide groups capable of acting as a PET fluorescent sensor for metal cationscitations
- 2001Spectral properties of 3-benzanthrone derivative dyes in isotropic solvents, polymer film and liquid crystal
- 2000Synthesis and characterisation of fluorescent polyacrylonitrile copolymers with 1,8-naphthalimide side chainscitations
Places of action
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article
New Iron(III)-Containing Composite of Salinomycinic Acid with Antitumor Activity—Synthesis and Characterization
Abstract
<p>In this study we demonstrated for the first time synthetic procedures for composites of salinomycin (SalH) and two-line ferrihydrite. The products were characterized by various methods such as elemental analysis, attenuated total reflectance–Fourier-transform spectroscopy (ATR-FTIR), electron paramagnetic resonance spectroscopy (EPR), powder X-ray diffraction analysis (XRD), electrospray-ionization mass spectrometry (ESI-MS), thermogravimetric analysis with differential thermal analysis (DTA) and mass spectrometry (TG-DTA/MS). The EPR spectra of the isolated compounds consisted of signals associated with both isolated Fe<sup>3+</sup> ions and magnetically coupled Fe<sup>3+</sup> ions. Powder XRD analyses of the isolated products showed two intense and broad peaks at 9° and 15° 2Θ, corresponding to salinomycinic acid. Broad peaks with very low intensity around 35°, assigned to two-line ferrihydrite, were also registered. Based on the experimental results, we concluded that salinomycin sodium reacted with Fe(III) chloride to form composites consisting of two-line ferrihydrite and salinomycinic acid. One of the composites exerted pronounced antitumor activity in the sub-micromolar concentration range against human cervical cancer (HeLa), non-small-cell lung cancer (A549), colon cancer (SW480), and ovarian teratocarcinoma (CH1/PA1) cells.</p>