| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Podlogar, Matejka
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2024Structural, microstructural and multiferroic properties of yttrium manganite ceramics co-doped with titanium and rare-earth metals
- 2023Heterogeneous nucleation and orientation relationships of icosahedral phase with TiB$_2$ inoculantscitations
- 2023The influence of spark plasma sintering temperature on the properties of Sb-doped barium stannate ceramics
- 2023Heterogeneous nucleation and orientation relationships of icosahedral phase with TiB2 inoculantscitations
- 2023Zirconia-toughened alumina ceramic wear particles do not elicit inflammatory responses in human macrophages
- 2023Degradation of polypropylene by fungi Coniochaeta hoffmannii and Pleurostoma richardsiae.citations
- 2022Tubular catalytic polyHIPE reactor with deposited silver nanoplate nanoparticlescitations
- 2022Effect of the sintering technique on the properties of Sb-doped BaSnO3 ceramics
- 2021Graphene-Based TiO2 Nanocomposite for Photocatalytic Degradation of Dyes in Aqueous Solution under Solar-Like Radiationcitations
- 2019The influence of sintering processing on microstructural, optical and electrical properties of zinc oxide ceramics doped with Al3+, B3+, Mg2+
- 2018Structural characterization of Inversion Boundaries in Doped ZnO
- 2017TEM study of basal-plane inversion boundaries in Sn‐Doped ZnO
Places of action
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article
Zirconia-toughened alumina ceramic wear particles do not elicit inflammatory responses in human macrophages
Abstract
Ten percent of patients undergoing total hip arthroplasty (THA) require revision surgery. One of the reasons for THA are wear particles released from the implants that can activate the immune defense and cause osteolysis and failure of the joint implant. The discrepancies between reports on toxicity and immunogenicity of the implant materials led us to this study in which we compared toxicity and immunogenicity of well-defined nanoparticles from Al$_2$O$_3$, zirconia-toughened alumina (ZTA), and cobalt chrome (CoCr), a human THP-1 macrophage cell line, human PBMCs, and therefrom-derived primary macrophages. None of the tested materials decreased the viability of THP-1 macrophages nor human primary macrophages at the 24 h time point, indicating that at concentrations from 0.05 to 50 µm$^3$/cell the tested materials are non-toxic. Forty-eight hours of treatment of THP-1 macrophages with 5 µm$^3$/cell of CoCr and Al$_2$O$_3$ caused 8.3-fold and 4.6-fold increases in TNF-α excretion, respectively, which was not observed for ZTA. The comparison between THP-1 macrophages and human primary macrophages revealed that THP-1 macrophages show higher activation of cytokine expression in the presence of CoCr and Al$_2$O$_3$ particles than primary macrophages. Our results indicate that ZTA is a non-toxic implant material with no immunogenic effects in vitro.