| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Gil, Fj
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2024SEM analysis and micro-CT evaluation of four dental implants after three different mechanical requests - in vitro studycitations
- 2023Effect of Fluoride Content of Mouthwashes on the Metallic Ion Release in Different Orthodontics Archwirescitations
- 2023Osteoblastic Cell Behavior and Gene Expression Related to Bone Metabolism on Different Titanium Surfaces.citations
- 2023Effect of fluoride content of mouthwashes on the metallic ion release in different orthodontics archwirescitations
- 2022Laser-deposited beta type Ti-42Nb alloy with anisotropic mechanical properties for pioneering biomedical implants with a very low elastic moduluscitations
- 2022Palladium nanoparticles synthesized by laser ablation in liquids for antimicrobial applicationscitations
- 2022Mechanical characterization of dental prostheses manufactured with PMMA–graphene compositescitations
- 2022Relevant Aspects of Titanium and Zirconia Dental Implants for Their Fatigue and Osseointegration Behaviorscitations
- 2021The role of hardness and roughness on the wear of different CoCrMo counterfaces on UHMWPE for artificial jointscitations
- 2021Biofunctional polyethylene glycol coatings on titanium: an in vitro-based comparison of functionalization methodscitations
- 2021Mechanical properties and corrosion behavior of Ti6Al4V particles obtained by implantoplasty: an in vitro study. Part IIcitations
- 2021In-situ laser directed energy deposition of biomedical Ti-Nb and Ti-Zr-Nb alloys from elemental powderscitations
- 2021Influence of different CoCrMo counterfaces on wear in UHMWPE for artificial jointscitations
- 2021Comparison of zirconia degradation in dental implants and femoral balls: an X-ray diffraction and nanoindentation studycitations
- 2020Fracture and fatigue of titanium narrow dental implants: new trends in order to improve the mechanical responsecitations
- 2020Mechanical properties of CoCr dental-prosthesis restorations made by three manufacturing processes: influence of the microstructure and topographycitations
- 2020Corrosion resistance and ion release of dental prosthesis of CoCr obtained by CAD-CAM milling, casting and laser sinteringcitations
- 2020NiTi superelastic orthodontic archwires with polyamide coatingcitations
- 2019Influence of the elastic modulus on the osseointegration of dental implantscitations
- 2018All-in-one trifunctional strategy: A cell adhesive, bacteriostatic and bactericidal coating for titanium implantscitations
- 2003Corrosion behaviour of commercially pure titanium shot blasted with different materials and sizes of shot particles for dental implant applicationscitations
Places of action
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article
Osteoblastic Cell Behavior and Gene Expression Related to Bone Metabolism on Different Titanium Surfaces.
Abstract
The surface topography of titanium dental implants has a great influence on osseointegration. In this work, we try to determine the osteoblastic behavior and gene expression of cells with different titanium surfaces and relate them to the physicochemical properties of the surface. For this purpose, we have used commercial titanium discs of grade 3: as-received corresponds to machined titanium without any surface treatment (MA), chemically acid etched (AE), treated via sand blasting with Al<sub>2</sub>O<sub>3</sub> particles (SB) and a sand-blasting treatment with acid etching (SB+AE). The surfaces have been observed using scanning electron microscopy (SEM) and the roughness, wettability and surface energy with dispersive and polar components have been characterized. Osteoblastic cultures were performed with SaOS-2 osteoblastic cells determining cell viability as well as alkaline phosphatase levels for 3 and 21 days, and osteoblastic gene expression was determined. The roughness values of the MA discs was 0.02 μm, which increases to 0.3 μm with acid attack and becomes the maximum for the sand-blasted samples, reaching values of 1.2 μm for SB and SB+AE. The hydrophilic behavior of the MA and AE samples with contact angles of 63° and 65° is superior to that of the rougher samples, being 75° for SB and 82° for SB+AE. In all cases, they show good hydrophilicity. GB and GB+AE surfaces present a higher polar component in the surface energy values, 11.96 and 13.18 mJ/m<sup>2</sup>, respectively, than AE and MA, 6.64 and 9.79 mJ/m<sup>2</sup>, respectively. The osteoblastic cell viability values at three days do not show statistically significant differences between the four surfaces. However, the viability of the SB and SB+AE surfaces at 21 days is much higher than that of the AE and MA samples. From the alkaline phosphatase studies, higher values were observed for those treated with sand blasting with and without acid etching compared to the other two surfaces, indicating a greater activity in osteoblastic differentiation. In all cases except in the Osterix (Ostx) -osteoblast-specific transcription factor-a decrease in gene expression is observed in relation to the MA samples (control). The most important increase was observed for the SB+AE condition. A decrease in the gene expression of Osteoprotegerine (OPG), Runt-related transcription factor 2 (Runx2), Receptor Activator of NF-κB Ligand (RANKL) and Alkaline Phosphatase (Alp) genes was observed in the AE surface.