| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Chiellini, Federica
University of Pisa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (26/26 displayed)
- 2022Smart Magnetic Nanocarriers for Multi-Stimuli On-Demand Drug Deliverycitations
- 2022Development and characterization of highly stable silver nanoparticles as novel potential antimicrobial agents for wound healing hydrogelscitations
- 2020Mono-, Di- and Tetra-iron Complexes with Selenium or Sulphur Functionalized Vinyliminium Ligands: Synthesis, Structural Characterization and Antiproliferative Activitycitations
- 2019Biomedical processing of polyhydroxyalkanoatescitations
- 2018Biofabrication via integrated additive manufacturing and electrofluidodynamicscitations
- 2017Additive manufacturing of poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] scaffolds for engineered bone developmentcitations
- 2017Additive Manufacturing of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/poly(ε-caprolactone) Blend Scaffolds for Tissue Engineeringcitations
- 2016Microstructured chitosan/poly(γ-glutamic acid) polyelectrolyte complex hydrogels by computer-aided wet-spinning for biomedical three-dimensional scaffoldscitations
- 2015Additive manufacturing techniques for the production of tissue engineering constructscitations
- 2014Preparation and characterization of biodegradable amphiphilic polymers and nanoparticles with high protein-loading capacitycitations
- 2013A new hydroxyapatite-based biocomposite for bone replacementcitations
- 2013Multiblock Copolymers of e–Caprolactone and Ethylene Glycol Containing Periodic Side-Chain Carboxyl Groups: Synthesis, Characterization, and Nanoparticle Preparationcitations
- 2012Synthesis and characterization of semi-interpenetrating polymer network hydrogel based on chitosan and poly(methacryloylglycylglycine)citations
- 2012Chalcone embedded polyurethanes as a biomaterial: Synthesis, characterization and antibacterial adhesion
- 2011Polymeric nanostructured items electrospun on a cylindrical template: A simple procedure for their removalcitations
- 2010Production of Bioglass® 45S5 - Polycaprolactone composite scaffolds via salt-leachingcitations
- 2010Novel electrospun polyurethane/gelatin composite meshes for vascular graftscitations
- 2010Preparation of stable dispersion of barium titanate nanoparticles: Potential applications in biomedicinecitations
- 2010Highly porous polycaprolactone-45s5 bioglass scaffolds for bone tissue engineeringcitations
- 2010Polymeric Materials for Bone and Cartilage Repaircitations
- 2009DI-(2-ETHYLHEXYL)PHTHALATE LEAKAGE AND COLOR CHANGES IN ENDOTRACHEAL TUBES AFTER APPLICATION IN HIGH-RISK NEWBORNScitations
- 2008Development of a bioactive glass fiber reinforced starch-polycaprolactone compositecitations
- 2008Di-(2-ethylhexyl)phthalate Leakage and Color Changes in Endotracheal Tubes after Application in High-Risk Newbornscitations
- 2008A New Biocompatible Nanoparticle Delivery System for the Release of Fibrinolytic Drugscitations
- 2006Bioerodible polymeric nanoparticles for targeted delivery of proteic drugscitations
- 2001Patterning of Polymeric Hydrogels for Biomedical Applications
Places of action
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article
Development and characterization of highly stable silver nanoparticles as novel potential antimicrobial agents for wound healing hydrogels
Abstract
Recurrent microbial infections are a major cause of surgical failure and morbidity. Wound healing strategies based on hydrogels have been proposed to provide at once a barrier against pathogen microbial colonization, as well as a favorable environment for tissue repair. Nevertheless, most biocompatible hydrogel materials are more bacteriostatic than antimicrobial materials, and lack specific action against pathogens. Silver-loaded polymeric nanocomposites have efficient and selective activity against pathogenic organisms exploitable for wound healing. However, the loading of metallic nanostructures into hydrogels represents a major challenge due to the low stability of metal colloids in aqueous environments. In this context, the aim of the present study was the development of highly stable silver nanoparticles (AgNPs) as novel potential antimicrobial agents for hyaluronic acids hydrogels. Two candidate stabilizing agents obtained from natural and renewable sources, namely cellulose nanocrystals and ulvan polysaccharide, were exploited to ensure high stability of the silver colloid. Both stabilizing agents possess inherent bioactivity and biocompatibility, as well as the ability to stabilize metal nanostructures thanks to their supramolecular structures. Silver nitrate reduction through sodium borohydride in presence of the selected stabilizing agents was adopted as a model strategy to achieve AgNPs with narrow size distribution. Optimized AgNPs stabilized with the two investigated polysaccharides demonstrated high stability in phosphate buffer saline solution and strong antimicrobial activity. Loading of the developed AgNPs into photocrosslinked methacrylated hyaluronic acid hydrogels was also investigated for the first time as an effective strategy to develop novel antimicrobial wound dressing materials. ; This research was supported by the Portuguese Foundation for Science and Technology (FCT) under the projects PTDC/BII-BIO/28870/2017 and POCI-01-0145-FEDER-007038 (UID/Multi/ 50026/2013), and by the European ...