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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Marques-Almeida, Teresa
University of Minho
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (4/4 displayed)
- 2022Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applicationscitations
- 2020Patterned Piezoelectric Scaffolds for Osteogenic Differentiationcitations
- 2018Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applicationscitations
- 2018Tailored Biodegradable and Electroactive Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Based Morphologies for Tissue Engineering Applicationscitations
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article
Tailored biodegradable and electroactive poly(hydroxybutyrate-co-hydroxyvalerate) based morphologies for tissue engineering applications
Abstract
Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompatible, biodegradable, and piezoelectric biopolymer that has been processed in different morphologies, including films, fibers, microspheres, and 3D scaffolds. The corresponding magnetically active PHBV-based composites were also produced. The effect of the morphology on physico-chemical, thermal, magnetic, and mechanical properties of pristine and composite samples was evaluated, as well as their cytotoxicity. It was observed that the morphology does not strongly affect the properties of the pristine samples but the introduction of cobalt ferrites induces changes in the degree of crystallinity that could affect the applicability of prepared biomaterials. Young’s modulus is dependent of the morphology and also increases with the addition of cobalt ferrites. Both pristine and PHBV/cobalt ferrite composite samples are not cytotoxic, indicating their suitability for tissue engineering applications. ; The authors thank the FCT (Fundação para a Ciência e Tecnologia) for financial support under the framework of strategic funding UID/FIS/04650/2013, UID/QUI/00686/2013, and UID/QUI/0686/2016; project PTDC/EEI-SII/5582/2014;andprojectPOCI-01-0145-FEDER-028237. FundsprovidedbyFCTintheframeworkof EuroNanoMed2016call,ProjectLungChekENMed/0049/2016arealsogratefullyacknowledged. D.M.C.andC.R. alsothanktheFCTforthegrantsSFRH/BPD/121526/2016andSFRH/BPD/90870/2012,respectively. Finally,the authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK and HAZITEK program. ; info:eu-repo/semantics/publishedVersion