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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Lotfian, Saeid
University of Strathclyde
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (22/22 displayed)
- 2023Low electric field induction in BaTiO3-epoxy nanocompositescitations
- 2023Low electric field induction in BaTiO3-epoxy nanocompositescitations
- 2023Effect of initial grain size on microstructure and mechanical properties of in situ hybrid aluminium nanocomposites fabricated by friction stir processingcitations
- 2023Low electric field induction in BaTiO 3 -epoxy nanocomposites
- 2023Bioactive and biodegradable polycaprolactone-based nanocomposite for bone repair applicationscitations
- 2022Development of an injectable shear-thinning nanocomposite hydrogel for cardiac tissue engineeringcitations
- 2022Assessment of mechanical and fatigue crack growth properties of wire + arc additively manufactured mild steel componentscitations
- 2022Mechanical stress measurement using phased array ultrasonic system
- 2022Mechanical Activation-Assisted Solid-State Aluminothermic Reduction of CuO Powders for In-Situ Copper Matrix Composite Fabricationcitations
- 2022Assessment of mechanical and fatigue crack growth properties of wire+arc additively manufactured mild steel componentscitations
- 2021Remanufacturing the AA5052 GTAW welds using friction stir processingcitations
- 2020Effect of multi-pass friction stir processing on textural evolution and grain boundary structure of Al-Fe3O4 systemcitations
- 2019Ultra-thin electrospun nanofibers for development of damage-tolerant composite laminatescitations
- 2019Development of damage tolerant composite laminates using ultra-thin interlaminar electrospun thermoplastic nanofibres
- 2019Towards the use of electrospun piezoelectric nanofibre layers for enabling in-situ measurement in high performance composite laminates
- 2018Electrospun piezoelectric polymer nanofiber layers for enabling in situ measurement in high-performance composite laminatescitations
- 2018Electrospun piezoelectric polymer nanofiber layers for enabling in situ measurement in high-performance composite laminatescitations
- 2018Development of damage tolerant composite laminates using ultra-thin interlaminar electrospun thermoplastic nanofibres
- 2018Towards the use of electrospun piezoelectric nanofibre layers for enabling in-situ measurement in high performance composite laminates
- 2015High temperature nanoindentation response of RTM6 epoxy resin at different strain ratescitations
- 2014Effect of layer thickness on the high temperature mechanical properties of Al/SiC nanolaminatescitations
- 2012High-temperature nanoindentation behavior of Al/SiC multilayerscitations
Places of action
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article
Development of an injectable shear-thinning nanocomposite hydrogel for cardiac tissue engineering
Abstract
Bone marrow-derived mesenchymal stem cells (MSCs) offer a promising therapeutic method for cardiac tissue regeneration. However, to monitor the fate of MSCs for tissue repair, a better stem cell delivery carrier is needed. Developing a unique injectable and shear-thinning dual cross-linked hybrid hydrogel for MSC delivery for cardiac tissue engineering is highly desirable. This hydrogel was synthesised using guest: host reaction based on alginate-cyclodextrin (Alg-CD) and adamantane-graphene oxide (Ad-GO). Here, the role of macromere concentration (10 and 12%) on the MSC function is discussed. Our hybrid hydrogels reveal a suitable oxygen pathway required for cell survival. However, this value is strongly dependent on the macromere concentrations, while the hydrogels with 12% macromere concentration (2DC12) significantly enhanced the oxygen permeability value (1.16-fold). Moreover, after two weeks of culture, rat MSCs (rMSCs) encapsulated in Alg-GO hydrogels expressed troponin T (TNT) and GATA4 markers. Noticeably, the 2DC12 hydrogels enhance rMSCs differentiation markers (1.30-times for TNT and 1.21-times for GATA4). Overall, our findings indicate that tuning the hydrogel compositions regulates the fate of encapsulated rMSCs within hydrogels. These outcomes may promote the advancement of new multifunctional platforms that consider the spatial and transient guidelines of undifferentiated cell destiny and capacity even after transplantation for heart tissue regeneration.