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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Corrigan, Damion
University of Strathclyde
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2023Comparing nanobody and aptamer-based capacitive sensing for detection of interleukin-6 (IL-6) at physiologically relevant levelscitations
- 2023Simple and low cost antibiotic susceptibility testing for mycobacterium tuberculosis using screen-printed electrodescitations
- 2022An electrochemical biosensor with integrated microheater to improve the sensitivity of electrochemical nucleic acid biosensorscitations
- 2021An electrochemical comparison of thiolated self-assembled monolayer (SAM) formation and stability in solution on macro- and nanoelectrodescitations
- 2020Impedance testing of porous Si3N4 scaffolds for skeletal implant applicationscitations
- 2019SAM composition and electrode roughness affect performance of a DNA biosensor for antibiotic resistancecitations
- 2019Development of a needle shaped microelectrode for electrochemical detection of the sepsis biomarker interleukin-6 (IL-6) in real timecitations
- 2018Novel nanofibre integrated SiN scaffolds for skeletal implant applications
- 2016Advances in electroanalysis, sensing and monitoring in molten saltscitations
- 2011Dielectrophoretic manipulation of ribosomal RNAcitations
Places of action
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article
SAM composition and electrode roughness affect performance of a DNA biosensor for antibiotic resistance
Abstract
Antibiotic resistance is a growing concern in the treatment of infectious disease worldwide. Point-of-care (PoC) assays which rapidly identify antibiotic resistance in a sample will allow for immediate targeted therapy which improves patient outcomes and helps maintain the effectiveness of current antibiotic stockpiles. Electrochemical assays offer many benefits, but translation from a benchtop measurement system to low-cost portable electrodes can be challenging.Using electrochemical and physical techniques, this study examines how different electrode surfaces and bio-recognition elements, i.e. the self-assembled monolayer (SAM), affect the performance of a biosensor measuring the hybridisation of a probe for antibiotic resistance to a target gene sequence in solution. We evaluate several commercially available electrodes which could be suitable for PoC testing with different SAM layers and show that electrode selection also plays an important role in overall biosensor performance.