• Sadidi, Hossein
• Kermani, Farzad
• Ahmadabadi, Ali
• Hoseini, Seyed Javad
• Tavousi, Seyed Hasan
• Nazarnezhad, Simin
• Rezapanah, Alireza
• Hosseini, Seyede Atefe
• Mollazadeh, Sahar
• Kargozar, Saeid

Abstract

<jats:p>In this study, we successfully utilized nitrate precursors for the synthesis of silver (Ag)-doped borate-based mesoporous bioactive glass (MBGs) based on the 1393B3 glass formulation in the presence of a polymeric substrate (polyvinyl alcohol (PVA)) as a stabilizer of boric acid. The X-ray diffraction (XRD) analysis confirmed the glassy state of all the MBGs. The incorporation of 7.5 mol% Ag into the glass composition led to a decrease in the glass transition temperature (Tg). Improvements in the particle size, zeta potential, surface roughness, and surface area values were observed in the Ag-doped MBGs. The MBGs (1 mg/mL) had no adverse effect on the viability of fibroblasts. In addition, Ag-doped MBGs exhibited potent antibacterial activity against gram-positive and gram-negative species. In summary, a modified sol–gel method was confirmed for producing the Ag-doped 1393B3 glasses, and the primary in vitro outcomes hold promise for conducting in vivo studies for managing burns.</jats:p>

Topics

• surface
• silver
• x-ray diffraction
• glass
• glass
• thermogravimetry
• glass transition temperature
• alcohol