Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (8/8 displayed)

  • 2023The Influence of Ionizing Radiation on Paclitaxel-Loaded Nanoparticles Based on PLGA6citations
  • 2016Understanding of Lithium 4,5-Dicyanoimidazolate-Poly(ethylene oxide) System: Influence of the Architecture of the Solid Phase on the Conductivity9citations
  • 2010Detailed studies on the fillers modification and their influence on composite, poly(oxyethylene)-based polymeric electrolytes74citations
  • 2007Structure, transport properties and interfacial stability of PVdF/HFP electrolytes containing modified inorganic filler74citations
  • 2006Physico- and electrochemistry of composite electrolytes based on PEODME–LiTFSI with TiO232citations
  • 2004Effect of cation and salt concentration on conductivity and microstructure characteristics of polyether electrolytes doped with alkali metal perchlorates13citations
  • 2003New poly(acrylamide) based (polymer in salt) electrolytes: preparation and spectroscopic characterization36citations
  • 2000Effect of filler surface group on ionic interactions in PEG−LiClO4−Al2O3 composite polyether electrolytes157citations

Places of action

Chart of shared publication
Kędra, Karolina
1 / 1 shared
Kowalczyk, Sebastian
1 / 4 shared
Cieśla, Krystyna
1 / 1 shared
Sobczak, Marcin
1 / 3 shared
Figat, Ramona
1 / 1 shared
Domańska, Izabela M.
1 / 1 shared
Ostrowski, Andrzej
1 / 5 shared
Żukowska, Grażyna
3 / 12 shared
Niedzicki, Leszek
2 / 5 shared
Korczak, Jędrzej
1 / 3 shared
Wieczorek, Władysław
7 / 19 shared
Marczewski, Maciej
1 / 4 shared
Dranka, Maciej
1 / 7 shared
Jankowski, Piotr
1 / 15 shared
Armand, Michel
1 / 15 shared
Syzdek, Jarosław
1 / 3 shared
Marcinek, Marek
2 / 8 shared
Stolarska, M.
1 / 1 shared
Borkowska, Regina
3 / 3 shared
Moskwiak, M.
1 / 1 shared
Giska, I.
1 / 1 shared
Marczewski, Marek
1 / 2 shared
Marczewska, Hanna
1 / 2 shared
Stygar, Jacek
1 / 1 shared
Biernat, Adam
1 / 1 shared
Rusiecka, A.
1 / 1 shared
Kwiatkowska, A.
1 / 1 shared
Lewandowski, P.
1 / 1 shared
Sułek, Emilia
1 / 1 shared
Pruszczyk, I.
1 / 1 shared
Bac, Artur
1 / 2 shared
Lipka, Paweł
1 / 1 shared
Chart of publication period
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Co-Authors (by relevance)

  • Kędra, Karolina
  • Kowalczyk, Sebastian
  • Cieśla, Krystyna
  • Sobczak, Marcin
  • Figat, Ramona
  • Domańska, Izabela M.
  • Ostrowski, Andrzej
  • Żukowska, Grażyna
  • Niedzicki, Leszek
  • Korczak, Jędrzej
  • Wieczorek, Władysław
  • Marczewski, Maciej
  • Dranka, Maciej
  • Jankowski, Piotr
  • Armand, Michel
  • Syzdek, Jarosław
  • Marcinek, Marek
  • Stolarska, M.
  • Borkowska, Regina
  • Moskwiak, M.
  • Giska, I.
  • Marczewski, Marek
  • Marczewska, Hanna
  • Stygar, Jacek
  • Biernat, Adam
  • Rusiecka, A.
  • Kwiatkowska, A.
  • Lewandowski, P.
  • Sułek, Emilia
  • Pruszczyk, I.
  • Bac, Artur
  • Lipka, Paweł
OrganizationsLocationPeople

article

The Influence of Ionizing Radiation on Paclitaxel-Loaded Nanoparticles Based on PLGA

  • Zalewska, Aldona
  • Kędra, Karolina
  • Kowalczyk, Sebastian
  • Cieśla, Krystyna
  • Sobczak, Marcin
  • Figat, Ramona
  • Domańska, Izabela M.
Abstract

<jats:p>The effect of ionizing radiation (γ-rays and electron beam) on anticancer drug delivery systems (DDSs) properties was evaluated concerning potential sterilization. For this purpose, paclitaxel (PTX)-loaded nanoparticles were obtained using a biodegradable, self-developed copolymer of l-lactide and glycolide (PLGA), synthesized in the presence of bismuth 2-ethylhexanoate catalyst. The nanoparticles were obtained with a high encapsulation efficiency of PTX (EE = 94.2%). The average size of the nanoparticles was 253.5 nm. The influence of irradiation (sterilization dose, 25 kGy) on the microstructure and the physicochemical and thermal properties of the polymer matrix was investigated, as well as the effect of irradiation on the morphology and physicochemical properties of the pharmaceutical formulations of the nanoparticles. Additionally, an in vitro drug release study was conducted regarding any alterations in the kinetic profiles of drug release. It was confirmed that the irradiation with both types of ionizing radiation, i.e., γ-rays and electron-beam (EB), slightly decreased the average molecular weight of the polymer matrix. While only negligible changes in the microstructure and thermal properties of PLGA were observed after irradiation with EB, the average length of lactidyl blocks (lLL) in the copolymer chains irradiated with γ-rays decreased from 4.33 to 3.35. Moreover, the contribution of crystalline phase (Xc) in γ-irradiated samples decreased significantly from 35.1% to 22.7%, suggesting a dominant mechanism of chain scission over cross-linking in PLGA samples irradiated with γ-rays. In vitro drug release results demonstrate a sustained and controlled release of PTX from the nanoparticles based on PLGA. The kinetics of drug release was defined as first order with non-Fickian diffusion. Only negligible differences in the kinetic profiles of PTX release from PLGA drug carriers were observed after irradiation. The overall results suggest good resistance of PLGA nanoparticles to irradiation within the conditions used and the great potential of EB in the sterilization process of the polymeric DDSs.</jats:p>

Topics
  • nanoparticle
  • microstructure
  • crystalline phase
  • molecular weight
  • copolymer
  • Bismuth