| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Torres, Yadir
Universidad de Sevilla
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2024Electrical impedance characterization and modelling of Ti‐Β implants
- 2023Ti6Al4V coatings on titanium samples by sputtering techniques: Microstructural and mechanical characterizationcitations
- 2023Limits of powder metallurgy to fabricate porous Ti35Nb7Zr5Ta samples for cortical bone replacementscitations
- 2023Thermal and tribo-mechanical properties of high-performance poly(etheretherketone)/reduced graphene oxide nanocomposite coatings prepared by electrophoretic depositioncitations
- 2022Fabrication and Characterization of Bioactive Gelatin–Alginate–Bioactive Glass Composite Coatings on Porous Titanium Substratescitations
- 2022Antimicrobial and Antibiofilm Effect of 4,4′-Dihydroxy-azobenzene against Clinically Resistant Staphylococcicitations
- 2021Effect of the Processing Parameters on the Porosity and Mechanical Behavior of Titanium Samples with Bimodal Microstructure Produced via Hot Pressingcitations
- 2020Porous Titanium Cylinders Obtained by the Freeze-Casting Technique: Influence of Process Parameters on Porosity and Mechanical Behaviorcitations
- 2020Characterization and Monitoring of Titanium Bone Implants with Impedance Spectroscopycitations
- 2020Characterization and Monitoring of Titanium Bone Implants with Impedance Spectroscopycitations
- 2020Influence of the Test Configuration and Temperature on the Mechanical Behaviour of WC-Cocitations
- 2020Surface Modification of Porous Titanium Discs Using Femtosecond Laser Structuringcitations
- 2020Surface Modification of Porous Titanium Discs Using Femtosecond Laser Structuringcitations
- 2019Fracture Toughness of Cemented Carbides Obtained by Electrical Resistance Sinteringcitations
- 2018Surface modification of Ti-6Al-4V alloys manufactured by selective laser melting: Microstructural and tribo-mechanical characterizationcitations
- 2017A new family of cermets: Chemically complex but microstructurally simplecitations
- 2016Electrophoretic Deposition of PEEK/45S5 Bioactive Glass Coating on Porous Titanium Substrate: Influence of Processing Conditions and Porosity Parameterscitations
- 2015Toughening of complete solid solution cermets by graphite additioncitations
Places of action
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article
Antimicrobial and Antibiofilm Effect of 4,4′-Dihydroxy-azobenzene against Clinically Resistant Staphylococci
Abstract
<jats:p>The spread of antibiotic resistance among human and animal pathogens is one of the more significant public health concerns. Moreover, the restrictions on the use of particular antibiotics can limit the options for the treatment of infections in veterinary clinical practice. In this context, searching for alternative antimicrobial substances is crucial nowadays. In this study, 4,4′-dihydroxy-azobenzene (DHAB) was tested for its potential in vitro as an antimicrobial agent against two relevant human and animal pathogens, namely Staphylococcus aureus and Staphylococcus pseudintermedius. The values of minimal inhibitory concentration (MIC) were 64 and 32 mg/L respectively, and they comparable to other azo compounds of probed antimicrobial activity. In addition, the minimal bactericidal concentrations (MCB) were 256 and 64 mg/L. The mechanism by which DHAB produces toxicity in staphylococci has been investigated. DHAB caused membrane damage as revealed by the increase in thiobarbituric acid reactive substances (TBARS) such as malondialdehyde. Furthermore, differential induction of the enzymes peroxidases and superoxide dismutase in S. aureus and S. pseudintermedius suggested their prevalent role in ROS-scavenging due to the oxidative burst induced by this compound in either species. In addition, this substance was able to inhibit the formation of biofilms by both bacteria as observed by colorimetric tests and scanning electron microscopy. In order to assess the relevance of DHAB against clinical strains of MRSA, 10 clinical isolates resistant to either methicillin or daptomycin were assayed; 80% of them gave values of CMI and CMB similar to those of the control S. aureus strain. Finally, cutaneous plasters containing a composite formed by an agar base supplemented with DHAB were designed. These plasters were able to inhibit in vitro the growth of S. aureus and S. pseudintermedius, particularly the later, and this suggests that this substance could be a promising candidate as an alternative to antibiotics in the treatment of animal skin infections, as it has been proven that the toxicity of this substance is very low particularly at a dermal level.</jats:p>