| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rahim, Abdur
in Cooperation with on an Cooperation-Score of 37%
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Publications (7/7 displayed)
- 2024The substantial role of TiO 2 in bimetallic alloy nanoparticle arrangement:electrocatalytic determination of glucose at Ni-Co@TiO 2 @GCE
- 2023Surface engineered mesoporous silica carriers for the controlled delivery of anticancer drug 5-fluorouracil: Computational approach for the drug-carrier interactions using density functional theorycitations
- 2023A highly explicit electrochemical biosensor for catechol detection in real samples based on copper-polypyrrolecitations
- 2022Recycled Coarse Aggregate for Sustainable Self-Compacting Concrete and Mortar
- 2022Recycled Coarse Aggregate for Sustainable Self-Compacting Concrete and Mortarcitations
- 2022Recycled Coarse Aggregate for Sustainable Self-Compacting Concrete and Mortarcitations
- 2021Designing and development of polyvinylpyrrolidone-tungsten trioxide (PVP-WO3) nanocomposite conducting film for highly sensitive, stable, and room temperature humidity sensingcitations
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article
Surface engineered mesoporous silica carriers for the controlled delivery of anticancer drug 5-fluorouracil: Computational approach for the drug-carrier interactions using density functional theory
Abstract
<jats:p><jats:bold>Introduction:</jats:bold> Drug delivery systems are the topmost priority to increase drug safety and efficacy. In this study, hybrid porous silicates SBA-15 and its derivatives SBA@N and SBA@3N were synthesized and loaded with an anticancer drug, 5-fluorouracil. The drug release was studied in a simulated physiological environment.</jats:p><jats:p><jats:bold>Method:</jats:bold> These materials were characterized for their textural and physio-chemical properties by scanning electron microscopy (SEM), nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), small-angle X-ray diffraction (SAX), and nitrogen adsorption/desorption techniques. The surface electrostatics of the materials was measured by zeta potential.</jats:p><jats:p><jats:bold>Results:</jats:bold> The drug loading efficiency of the prepared hybrid materials was about 10%. <jats:italic>In vitro</jats:italic> drug release profiles were obtained in simulated fluids. Slow drug release kinetics was observed for SBA@3N, which released 7.5% of the entrapped drug in simulated intestinal fluid (SIF, pH 7.2) and 33% in simulated body fluid (SBF, pH 7.2) for 72 h. The material SBA@N presented an initial burst release of 13% in simulated intestinal fluid and 32.6% in simulated gastric fluid (SGF, pH 1.2), while about 70% of the drug was released within the next 72 h. Density functional theory (DFT) calculations have also supported the slow drug release from the SBA@3N material. The release mechanism of the drug from the prepared carriers was studied by first-order, second-order, Korsmeyer–Peppas, Hixson–Crowell, and Higuchi kinetic models. The drug release from these carriers follows Fickian diffusion and zero-order kinetics in SGF and SBF, whereas first-order, non-Fickian diffusion, and case-II transport were observed in SIF.</jats:p><jats:p><jats:bold>Discussion:</jats:bold> Based on these findings, the proposed synthesized hybrid materials may be suggested as a potential drug delivery system for anti-cancer drugs such as 5-fluorouracil.</jats:p>