| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Paiva, Alexandre
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (45/45 displayed)
- 2024Exploring the biological properties and bioaccessibility of orange peel extracts using deep eutectic systemscitations
- 2023Using Natural Deep Eutectic Systems as Alternative Media for Ocular Applicationscitations
- 2023Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healingcitations
- 2023Hydrophobic DES Based on Menthol and Natural Organic Acids for Use in Antifouling Marine Coatingscitations
- 2023Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systemscitations
- 2023Improving the activity of horseradish peroxidase in betaine-based natural deep eutectic systemscitations
- 2023Improving the activity of horseradish peroxidase in betaine-based natural deep eutectic systemscitations
- 2023Is it possible to correlate various physicochemical properties of Natural Deep eutectic systems in order to predict their behaviours as solvents?citations
- 2023Is it possible to correlate various physicochemical properties of Natural Deep eutectic systems in order to predict their behaviours as solvents?citations
- 2022Selective terpene based therapeutic deep eutectic systems against colorectal cancercitations
- 2022On the Not So Anomalous Water-induced Structural Transformations of Choline Chloride-Urea (Reline) Deep Eutectic Systemcitations
- 2022Fractionated extraction of polyphenols from mate tea leaves using a combination of hydrophobic/ hydrophilic NADEScitations
- 2022Fractionated extraction of polyphenols from mate tea leaves using a combination of hydrophobic/ hydrophilic NADEScitations
- 2022Subcritical Water as a Pre-Treatment of Mixed Microbial Biomass for the Extraction of Polyhydroxyalkanoatescitations
- 2022Subcritical Water as a Pre-Treatment of Mixed Microbial Biomass for the Extraction of Polyhydroxyalkanoatescitations
- 2022Assessing the Influence of Betaine-Based Natural Deep Eutectic Systems on Horseradish Peroxidasecitations
- 2022Assessment of deep eutectic solvents toxicity in zebrafish (Danio rerio)citations
- 2022Selective extraction and stabilization of bioactive compounds from rosemary leaves using a biphasic NADEScitations
- 2021Natural deep eutectic systems—A new era of cryopreservationcitations
- 2021Effect of water on the structure and dynamics of choline chloride/glycerol eutectic systemscitations
- 2021Evaluation of Deep Eutectic Systems as an Alternative to Solvents in Painting Conservationcitations
- 2021Deep eutectic systems from betaine and polyols – Physicochemical and toxicological propertiescitations
- 2021Improved storage of influenza HA-VLPs using a trehalose-glycerol natural deep eutectic solvent systemcitations
- 2021Unravelling the nature of citric acid:l-arginine:water mixtures ; The bifunctional role of watercitations
- 2021Low-Phytotoxic Deep Eutectic Systems as Alternative Extraction Media for the Recovery of Chitin from Brown Crab Shellscitations
- 2021Low-Phytotoxic Deep Eutectic Systems as Alternative Extraction Media for the Recovery of Chitin from Brown Crab Shellscitations
- 2021Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservationcitations
- 2020Design and processing of drug delivery formulations of therapeutic deep eutectic systems for tuberculosiscitations
- 2020Terpene-Based Natural Deep Eutectic Systems as Efficient Solvents to Recover Astaxanthin from Brown Crab Shell Residuescitations
- 2019Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solventscitations
- 2019Therapeutic Role of Deep Eutectic Solvents Based on Menthol and Saturated Fatty Acids on Wound Healingcitations
- 2018Synthesis and Physical and Thermodynamic Properties of Lactic Acid and Malic Acid-Based Natural Deep Eutectic Solventscitations
- 2018Natural deep eutectic systems as alternative nontoxic cryoprotective agentscitations
- 2017Production of Electrospun Fast-Dissolving Drug Delivery Systems with Therapeutic Eutectic Systems Encapsulated in Gelatincitations
- 2017A comparison between pure active pharmaceutical ingredients and therapeutic deep eutectic solventscitations
- 2017Green solvents for enhanced impregnation processes in biomedicinecitations
- 2017Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatincitations
- 2017Stabilizing Unstable Amorphous Menthol through Inclusion in Mesoporous Silica Hostscitations
- 2016Solubility and Permeability Enhancement of active compounds: Therapeutic Deep Eutectic Systems as New Vehicles for Drug Deliverycitations
- 2016Dissolution enhancement of active pharmaceutical ingredients by therapeutic deep eutectic systemscitations
- 2015Design of controlled release systems for THEDES - Therapeutic deep eutectic solvents, using supercritical fluid technologycitations
- 2015Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technologycitations
- 2015Coupling Thedes - Therapeutic Deep Eutectic Solvents And Supercritical Fluid Technology for the Development of Controlled Delivery Systemscitations
- 2014Conversion of fat-containing waste from the margarine manufacturing process into bacterial polyhydroxyalkanoatescitations
- 2014Production of polyhydroxyalkanoates from spent coffee grounds oil obtained by supercritical fluid extraction technologycitations
Places of action
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article
Selective extraction and stabilization of bioactive compounds from rosemary leaves using a biphasic NADES
Abstract
Publisher Copyright: Copyright © 2022 Vieira, Rebocho, Craveiro, Paiva and Duarte. ; Rosemary (Rosmarinus officinalis) is a natural source of bioactive compounds that have high antioxidant activity. It has been in use as a medicinal herb since ancient times, and it currently is in widespread use due to its inherent pharmacological and therapeutic potential, in the pharmaceutical, food, and cosmetic industries. Natural deep eutectic systems (NADESs) have recently been considered as suitable extraction solvents for bioactive compounds, with high solvent power, low toxicity, biodegradability, and low environmental impact. The present work concerns the extraction of compounds such as rosmarinic acid, carnosol, carnosic acid, and caffeic acid, from rosemary using NADESs. This extraction was carried out using heat and stirring (HS) and ultrasound-assisted extraction (UAE). A NADES composed of menthol and lauric acid at a molar ratio of 2:1 (Me:Lau) extracted carnosic acid and carnosol preferentially, showing that this NADES exhibits selectivity for nonpolar compounds. On the other hand, a system of lactic acid and glucose (LA:Glu (5:1)) extracted preferentially rosmaniric acid, which is a more polar compound. Taking advantage of the different polarities of these NADESs, a simultaneous extraction was carried out, where the two NADESs form a biphasic system. The system LA:Glu (5:1)/Men:Lau (2:1) presented the most promising results, reaching 1.00 ± 0.12 mg of rosmarinic acid/g rosemary and 0.26 ± 0.04 mg caffeic acid/g rosemary in the more polar phase and 2.30 ± 0.18 mg of carnosol/g of rosemary and 17.54 ± 1.88 mg carnosic acid/g rosemary in the nonpolar phase. This work reveals that is possible to use two different systems at the same time and extract different compounds in a single-step process under the same conditions. NADESs are also reported to stabilize bioactive compounds, due to their interactions established with NADES components. To determine the stability of the extracts over time, the compounds of interest ...