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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Moosmann, Julian
Helmholtz-Zentrum Hereon
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (20/20 displayed)
- 2024Unveiling thermo‐fluid dynamic phenomena in laser beam welding
- 2024Exploring spatial beam shaping in laser powder bed fusion:High-fidelity simulation and in-situ monitoringcitations
- 2024Improvement of corrosion resistance of PEO coated dissimilar Ti/Mg0.6Ca couplecitations
- 2024Improvement of corrosion resistance of PEO coated dissimilar Ti/Mg0.6Ca couplecitations
- 2024Towards an Understanding of the Challenges in Laser Beam Welding of Copper - Observation of the Laser-Matter Interaction Zone in Laser Beam Welding of Copper and Steel Using in Situ Synchrotron X-Ray Imagingcitations
- 2024Pull‐Out Testing of Electrochemically Etched NiTi Shape Memory Alloy Wires in Shape Memory Alloy Hybrid Composites
- 2024Pull‐Out Testing of Electrochemically Etched NiTi Shape Memory Alloy Wires in Shape Memory Alloy Hybrid Composites
- 2024Challenges in non-destructive X-ray CT testing of riveted joints in the automotive industrycitations
- 2023Interface failure analysis of embedded NiTi SMA wires using in situ high-resolution X-ray synchrotron tomographycitations
- 2023Analysis on the influence of vapor capillary aspect ratio on pore formation in laser beam welding of aluminumcitations
- 2023Towards an Understanding of the Challenges in Laser Beam Welding of Copper – Observation of the Laser-Matter Interaction Zone in Laser Beam Welding of Copper and Steel Using in Situ Synchrotron X-Ray Imagingcitations
- 2022Assessing the long-term in vivo degradation behavior of magnesium alloys - a high resolution synchrotron radiation micro computed tomography studycitations
- 2022Pore Formation and Melt Pool Analysis of Laser Welded Al-Cu Joints using Synchrotron Radiationcitations
- 2022Pore formation and melt pool analysis of laser welded Al-Cu joints using synchrotron radiationcitations
- 2021Assessing the microstructure and in vitro degradation behavior of Mg-xGd screw implants using µCTcitations
- 2021Assessing the microstructure and in vitro degradation behavior of Mg-xGd screw implants using µCTcitations
- 2021Multimodal ex vivo methods reveal that Gd-rich corrosion byproducts remain at the implant site of biodegradable Mg-Gd screwscitations
- 2019A load frame for in situ tomography at PETRA IIIcitations
- 2019A load frame for in situ tomography at PETRA IIIcitations
- 2018Visualization of Implant Failure by Synchrotron Tomographycitations
Places of action
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article
Assessing the long-term in vivo degradation behavior of magnesium alloys - a high resolution synchrotron radiation micro computed tomography study
Abstract
Biodegradable magnesium (Mg) implants are emerging as a potential game changer in implant technology in situations where the implant temporarily supports the bone thereby avoiding secondary surgery for implant removal. However, the consequences of the alteration in the degradation rate to bone healing and the localization of degradation and alloying products in the long term remain unknown. In this study, we present the long-term osseointegration of three different biodegradable Mg alloys, Mg-10Gd, Mg-4Y-3RE and Mg-2Ag, which were implanted into rabbit femur for 6 and 9 months. In addition, we have investigated the effect of blood pre-incubation on the in vivo performance of the aforementioned alloys. Using high-resolution synchrotron radiation based micro computed tomography, the bone implant contact (BIC), bone volume fraction (BV/TV) and implant morphology were studied. The elemental traces have been characterized using micro X-ray fluorescence. Qualitative histological evaluation of the surrounding bone was also performed. Matured bone formed around all three implant types and Ca as well as P which represent parts of the degradation layer were in intimate contact with the bone. Blood pre-incubation prior to implantation significantly improved BIC in Mg-2Ag screws at 9 months. Despite different implant degradation morphologies pointing toward different degradation dynamics, Mg-10Gd, Mg-4Y-3RE and Mg-2Ag induced a similar long-term bone response based on our quantified parameters. Importantly, RE elements Gd and Y used in the alloys remained at the implantation site implying that they might be released later on or might persist in the implantation site forever. As the bone formation was not disturbed by their presence, it might be concluded that Gd and Y are non-deleterious. Consequently, we have shown that short and mid-term in vivo evaluations do not fully represent indicators for long-term osseointegration of Mg-based implants.