| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Nigmatullin, Rinat
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 20243D Melt-Extrusion Printing of Medium Chain Length Polyhydroxyalkanoates and Their Application as Antibiotic-Free Antibacterial Scaffolds for Bone Regenerationcitations
- 2021Antibacterial Composite Materials Based on the Combination of Polyhydroxyalkanoates With Selenium and Strontium Co-substituted Hydroxyapatite for Bone Regenerationcitations
- 2020Antimicrobial materials with lime oil and a poly(3-hydroxyalkanoate) produced via valorisation of sugar cane molassescitations
- 2020Modulation of neuronal cell affinity of composite scaffolds based on polyhydroxyalkanoates and bioactive glassescitations
- 2019Cellulose nanocrystal-polyetherimide hybrid nanofibrous interleaves for enhanced interlaminar fracture toughness of carbon fibre/epoxy compositescitations
- 2019Thermosensitive supramolecular and colloidal hydrogels via self-assembly modulated by hydrophobized cellulose nanocrystalscitations
- 2018High Stiffness Cellulose Fibers from Low Molecular Weight Microcrystalline Cellulose Solutions Using DMSO as Co-Solvent with Ionic Liquidcitations
- 2018Binary polyhydroxyalkanoate systems for soft tissue engineeringcitations
- 2009Permanent, Non-Leaching Antimicrobial Polyamide Nanocomposites Based on Organoclays Modified with a Cationic Polymer
- 2008Polymer-layered silicate nanocomposites in the design of antimicrobial materials
Places of action
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article
Antibacterial Composite Materials Based on the Combination of Polyhydroxyalkanoates With Selenium and Strontium Co-substituted Hydroxyapatite for Bone Regeneration
Abstract
<jats:p>Due to the threat posed by the rapid growth in the resistance of microbial species to antibiotics, there is an urgent need to develop novel materials for biomedical applications capable of providing antibacterial properties without the use of such drugs. Bone healing represents one of the applications with the highest risk of postoperative infections, with potential serious complications in case of bacterial contaminations. Therefore, tissue engineering approaches aiming at the regeneration of bone tissue should be based on the use of materials possessing antibacterial properties alongside with biological and functional characteristics. In this study, we investigated the combination of polyhydroxyalkanoates (PHAs) with a novel antimicrobial hydroxyapatite (HA) containing selenium and strontium. Strontium was chosen for its well-known osteoinductive properties, while selenium is an emerging element investigated for its multi-functional activity as an antimicrobial and anticancer agent. Successful incorporation of such ions in the HA structure was obtained. Antibacterial activity against <jats:italic>Staphylococcus aureus</jats:italic> 6538P and <jats:italic>Escherichia coli</jats:italic> 8739 was confirmed for co-substituted HA in the powder form. Polymer-matrix composites based on two types of PHAs, P(3HB) and P(3HO-co-3HD-co-3HDD), were prepared by the incorporation of the developed antibacterial HA. An in-depth characterization of the composite materials was conducted to evaluate the effect of the filler on the physicochemical, thermal, and mechanical properties of the films. <jats:italic>In vitro</jats:italic> antibacterial testing showed that the composite samples induce a high reduction of the number of <jats:italic>S. aureus</jats:italic> 6538P and <jats:italic>E. coli</jats:italic> 8739 bacterial cells cultured on the surface of the materials. The films are also capable of releasing active ions which inhibited the growth of both Gram-positive and Gram-negative bacteria.</jats:p>