| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Scarpa, Fabrizio L.
University of Bristol
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (33/33 displayed)
- 2024Assessment of damping and flexural behaviour of hybrid fibre-particulate composites
- 2024Quantifying efficient shape-shiftingcitations
- 2024Using a Negative Poisson's Ratio to Mitigate Stress Concentrations in Perforated Composite Platescitations
- 2024Flax fibre reinforced alginate poloxamer hydrogelcitations
- 2023Statistical evaluation of three-point bending properties of sustainable aluminium sandwich panels with arched-core geometrycitations
- 2023Design space and manufacturing of programmable 4D printed continuous flax fibre polylactic acid composite hygromorphscitations
- 2022The influence of the humidity on the mechanical properties of 3D printed continuous flax fibre reinforced poly(lactic acid) compositescitations
- 2022The Design of 4D-Printed Hygromorphscitations
- 2022Numerical and experimental investigations on sandwich panels made with eco-friendly components under low-velocity impactcitations
- 2021Multiphase lattice metamaterials with enhanced mechanical performancecitations
- 2021Transverse fastening reinforcement of sandwich panels with upcycled bottle caps corecitations
- 2020Chondroinduction of Mesenchymal Stem Cells on Cellulose-Silk Composite nanofibrous Substratescitations
- 2020Ageing of autoclaved epoxy/flax composites:effects on water absorption, porosity and flexural behaviourcitations
- 2020Cactus-based solids and bio-composites for energy dissipation in defence and biomedical applications.
- 2020Development of Cycloaliphatic Epoxy-POSS Nanocomposite Matrices with Enhanced Resistance to Atomic Oxygencitations
- 2020Thermoformability characterisation of Flax reinforced polypropylene composite materialscitations
- 2020Transverse fastening reinforcement of sandwich panels with upcycled bottle caps corecitations
- 2020Abnormal stiffness behaviour in artificial cactus-inspired reinforcement materialscitations
- 2020Tensile and flexural properties of epoxy laminates with natural papaya bast fibre cellular layerscitations
- 2020Eco-friendly Sandwich Panel Based on Recycled Bottle Caps Core and Natural Fibre Composite Facingscitations
- 2019Microwave Properties of Metacomposites Containing Carbon Fibres and Ferromagnetic Microwirescitations
- 2018Repair Of Reinforced Concrete Beams In Shear Using Composite Materials Prfg Subjected To Cyclic Loading
- 2018Behaviour Of Reinforced Columns With E_Glass Fiber And Carbon Fiber
- 2018Effects Of Adding Sisal And Glass Fibers On The Mechanical Behaviour Of Concrete Polymercitations
- 2017Mechanics and band gaps in hierarchical auxetic rectangular perforated composite metamaterialscitations
- 2017Hybrid silica micro and PDDA/nanoparticles-reinforced carbon fibre compositescitations
- 2017Piezoelectric effects in boron nitride nanotubes predicted by the atomistic finite element method and molecular mechanicscitations
- 2016Influence of nanorubber toughening on the tensile deformation and tensile fatigue behaviour of a carbon fibre-reinforced epoxy compositecitations
- 2016Blocked Shape Memory Effect in Negative Poisson's Ratio Polymer Metamaterialscitations
- 2016Morphing hybrid honeycomb (MOHYCOMB) with in situ Poisson's ratio modulationcitations
- 2016Fabrication and Characterisation of Polyurethane/Sepiolite Polymer Nanocomposite Foams for Enhanced Energy Absorption
- 2014Shape memory polymer hexachiral auxetic structures with tunable stiffnesscitations
- 2012Design of a deployable structure with shape memory polymerscitations
Places of action
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article
Chondroinduction of Mesenchymal Stem Cells on Cellulose-Silk Composite nanofibrous Substrates
Abstract
Smart biomaterials with an inherent capacity to elicit specific behaviours in lieu of biological prompts are advantageous for regenerative medicine applications. In this work, we employ an electrospinning technique to model the in vivo nanofibrous extracellular matrix (ECM) of cartilage using a chondroinductive cellulose and silk polymer blend (75:25 ratio). This natural polymer composite is directly electrospun for the first time, into nanofibers without post-spun treatment, using a trifluoroacetic acid and acetic acid cosolvent system. Biocompatibility of the composite with human mesenchymal stem cells (hMSCs) is demonstrated and its inherent capacity to direct chondrogenic stem cell differentiation, in the absence of stimulating growth factors, is confirmed. This chondrogenic stimulation could be countered biochemically using fibroblast growth factor-2, a growth factor used to enhance the proliferation of hMSCs. Furthermore, the potential mechanisms driving this chondroinduction at the cell-biomaterial interface were investigated. Composite substrates were fabricated as two-dimensional film surfaces and cultured with hMSCs in the presence of chemicals that interfere with their biochemical and mechanical signalling pathways. Preventing substrate surface elasticity transmission resulted in significant downregulation of chondrogenic gene expression. Interference with the classical chondrogenic Smad2/3 phosphorylation pathway did not impact chondrogenesis. The results highlight the importance of substrate mechanical elasticity on hMSCs chondroinduction and its independence to known chondrogenic biochemical pathways. The newly fabricated scaffolds provide the foundation for designing a robust, self-inductive, and cost-effective biomimetic, natural biomaterial for cartilage tissue engineering.