| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Singh, Jagtar
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2019Nano scratch and Nanoindentation: An Approach to Understand the Tribological Behaviour of Max Phase Material Ti<sub>2</sub>AlCcitations
- 2018A novel study to examine the association of PCSK9 rs505151 polymorphism and coronary artery disease in north Indian population.citations
- 2014High risk association of IL-4 VNTR polymorphism with asthma in a North Indian population.citations
- 2014Association of 24 bp duplication of human CHIT1 gene with asthma in a heterozygous population of north India: a case-control study.citations
- 2012Genetic polymorphisms in the P2X7 gene and its association with susceptibility to tuberculosis.citations
- 2012Protective role of IL-18 -137G/C polymorphism in a North Indian population with asthma: a pilot study.citations
- 2011No Association of<i>PTGDR</i><i>−441C/T</i>Polymorphism with Asthma in a North Indian Populationcitations
- 2011No association of PTGDR -441C/T polymorphism with asthma in a North Indian population.citations
Places of action
| Organizations | Location | People |
|---|
article
No association of PTGDR -441C/T polymorphism with asthma in a North Indian population.
Abstract
BACKGROUND: Asthma is the most prevalent disease in India according to the national survey conducted by NFHS 2 in 1998-399. Prostaglandin D2 (PGD2) is a bronchoconstriction inducing metabolite of arachidonic acid in the mast cells, which is produced on exposure to allergens and acts as a ligand for the Prostaglandin D2 Receptor (PTGDR). Polymorphisms in the PTGDR gene have been suggested to be involved in the mechanism of asthma. OBJECTIVE: This is the first study conducted in India, investigating the role of PTGDR -441C/T} promoter polymorphism in asthma pathogenesis. METHODS: A case-control study was performed with a total of 992 subjects, including 410 adult asthmatics and 582 healthy controls from regions of North India. The PTGDR -441C/T polymorphism was genotyped by Tetra-Primer Amplification Refractory Mutation System Polymerase Chain Reaction (Tetra-Primer ARMS PCR). RESULTS: Statistical analysis of the results between asthma cases and controls for the PTGDR −441C/T polymorphism showed Chi² (χ²) = 0.29, OR = 0.95, 95% CI (0.70-1.15) and p = 0.599. Neither the genotypic nor the allelic frequencies observed for the PTGDR −441C/T polymorphism, were significantly associated with asthma or asthma phenotypes. CONCLUSIONS: The PTGDR -441C/T polymorphism is not associated with asthma or its phenotypes in the studied North Indian population.