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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Liu, H.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (39/39 displayed)
- 2024Comparison of X-ray Computed Tomography and Ultrasonic C-Scan Techniques and Numerical Modelling of Impact Damage in a CFRP Composite Laminatecitations
- 2023Tunable unconventional kagome superconductivity in charge ordered RbV3Sb5 and KV3Sb5citations
- 2022The Effects of Surfaces and Surface Passivation on the Electrical Properties of Nanowires and Other Nanostructures: Time-Resolved Terahertz Spectroscopy Studies
- 2022The effectiveness of patch repairs to restore the impact properties of carbon-fibre reinforced-plastic compositescitations
- 20223D In-situ Stop Action Study of Recrystallization in Additively Manufactured 316L Stainless Steel: Reconstruction Optimization and Observationscitations
- 2022Experimental and numerical investigations on the impact behaviour of pristine and patch-repaired composite laminatescitations
- 2022f-electron hybridised Fermi surface in magnetic field-induced metallic YbB12citations
- 2022PAWG Pilot Study on Quantification of SARS-CoV-2 Monoclonal Antibody - Part 1citations
- 2021The effect of a coupling agent on the impact behavior of flax fibre composites
- 2021“Inside out” growth method for high-quality nitrogen-doped graphenecitations
- 2021Influence of diameter on temperature dynamics of hot carriers in photoexcited GaAsP nanowires
- 2021Cranberry Juice Extract Rapidly Protects Demineralized Dentin against Digestion and Inhibits Its Gelatinolytic Activity.citations
- 2019Improvement of the stabilization loops performances of a DF-VECSEL dedicated to cesium CPT clocks application by fully-correlated multi-mode pumpingcitations
- 2019DEVELOPMENT OF THE BRICAN TD100 SMALL UAS AND PAYLOAD TRIALScitations
- 2019Gallium Phosphide photoanode coated with TiO₂ and CoOₓ for stable photoelectrochemical water oxidation
- 2018Noise investigation of a dual-frequency VECSEL for application to cesium clockscitations
- 2018Strategies for noise reduction of a dual-frequency VECSEL dedicated to cesium CPT clocks
- 2018TiO2 nanofiber photoelectrochemical cells loaded with sub-12 nm AuNPs: Size dependent performance evaluation
- 2018Blast resilience of composite sandwich panels with hybrid glass-fibre and carbon-fibre skinscitations
- 2017Multiscale modelling of the morphology and spatial distribution of theta' precipitates in Al-Cu alloyscitations
- 2017Noise measurement and modeling of a dual-frequency VECSEL at cesium clock wavelengthcitations
- 2017Accelerated degradation of polymer electrolyte membrane fuel cell gas diffusion layers. III. Mass transport resistance and liquid water accumulation at limiting current density with in operando synchrotron X-ray radiographycitations
- 2016Nanopatterning of Octadecyltrichlorosilane (OTS) Self-Assembled Monolayers By Probe-based Lithography: Extending the Range of Substrates
- 2016Active Millimeter-Wave Radiometry for Nondestructive Testing/Evaluation of Composites--Glass Fiber Reinforced Polymercitations
- 2015DEVELOPMENT OF THE BRICAN TD100 SMALL UAS AND PAYLOAD TRIALScitations
- 2015Behavior of alloying elements during anodizing of Mg-Cu and Mg-W alloys in a fluoride/glycerol electrolytecitations
- 2015Behavior of alloying elements during anodizing of Mg-Cu and Mg-W alloys in a fluoride/glycerol electrolytecitations
- 2015Behavior of alloying elements during anodizing of Mg-Cu and Mg-W alloys in a fluoride/glycerol electrolytecitations
- 2015Tunable optical buffer based on III-V MEMS design
- 2015Analyses of the Sequential Stages of Corrosion on AA2024T3 Using the Scanning Vibrating Electrode Technique (SVET)citations
- 2014Formation of barrier-type anodic films on ZE41 magnesium alloy in a fluoride/glycerol electrolytecitations
- 2014Formation of barrier-type anodic films on ZE41 magnesium alloy in a fluoride/glycerol electrolytecitations
- 2012Nickel-boron plating on magnesium and AZ91D alloy by a chromium-free electroless processcitations
- 2012Porous anodic film formation on Al-Ti alloys in sulphuric acidcitations
- 2010Bone marrow mesenchymal stromal cells with support of bispecific antibody and ultrasound-mediated microbubbles prevent myocardial fibrosis via the signal transducer and activators of transcription signaling pathway.citations
- 2010Laser-induced microstructural modification for corrosion protectioncitations
- 2009Self healing cementitious composites for sustainble infrastructures
- 2009Self-healing cementitious composites under bending loads
- 2000Microstructure and properties of monazite (LaPO 4 ) coated saphikon fiber/alumina matrix compositescitations
Places of action
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article
Bone marrow mesenchymal stromal cells with support of bispecific antibody and ultrasound-mediated microbubbles prevent myocardial fibrosis via the signal transducer and activators of transcription signaling pathway.
Abstract
<h4>Background aims</h4>This study was initiated to investigate the efficacy of myocardial fibrosis intervention via signal transducer and activators of transcription (STAT) signaling using bone marrow (BM) mesenchymal stromal cells (MSC) with the aid of bispecific antibody (BiAb) and ultrasound-mediated microbubbles (MB).<h4>Methods</h4>BiAb (anti-CD29 × anti-myosin light chain antibody; AMLCA) was prepared and combined with isolated MSC from male mice and transfused into female mice with isoproterenol-induced myocardial fibrosis via the tail vein, followed by MB (MSC + BiAb + MB). This study included seven groups: MSC + BiAb + MB; MSC; BiAb; MB; MSC + BiAb; untreated; and control. Five weeks after treatment, expression levels of the sex-determining region of Y-chromosome (SRY), matrix metalloproteinases (MMP)-9, tissue inhibitor of metalloproteinase (TIMP)-1 and vascular endothelial growth factor (VEGF) in myocardium were detected by fluorescent quantitative real-time polymerase chain reaction (qRT-PCR). Collagen distribution was observed using Sirius Red staining. The protein expression of signal transducer and activators of transcription (STAT)1 and STAT3 was detected by Western blot.<h4>Results</h4>The highest homing number of MSC was in the MSC + BiAb + MB group, second highest in the MSC + BiAb group, and lowest in MSC alone. Compared with the untreated group, MSC + BiAb + MB, MSC + BiAb and MSC groups had decreased levels of MMP-9, TIMP-1, STAT1 and collagen deposition, and increased levels of STAT3. Upregulated STAT3 and downregulated TIMP-1 were significantly different in MSC + BiAb + MB compared with MSC alone or MSC + BiAb.<h4>Conclusions</h4>The homing rate and repairing efficacy of MSC improved with treatment utilizing a combination of BiAb and MB. MSC can improve MMP-TIMP expression in injured myocardium and interfere with myocardial fibrosis after homing, a mechanism that may be related to the STAT-mediated signaling pathway.