| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Repo, Timo
University of Helsinki
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Mesoporous silica-amine beads from blast furnace slag for CO<sub>2</sub> capture applicationscitations
- 2023Functionalization of nitrogen-doped graphene quantum dotcitations
- 2022Parahydrogen-induced polarization study of imine hydrogenations mediated by a metal-free catalystcitations
- 2017Nuclear spin hyperpolarization with ansa-aminoboranes : a metal-free perspective for parahydrogen-induced polarizationcitations
- 2016Nuclear spin hyperpolarization with ansa-aminoboranescitations
- 2016Towards improved solubility of poorly water-soluble drugscitations
- 2014Tweezers for Parahydrogencitations
- 2011Two- and three-dimensional packing diagrams of M(salophen) complexescitations
- 2006Synthesis of titanium complexes bearing two mono anionic malonic acid ester based ligands and their use as catalyst precursors in ethene polymerizationcitations
- 2006High-molar-mass polypropene with tunable elastic properties by hafnocene/borate catalystscitations
- 2004Tetrakis Sn(IV) alkoxides as novel initiators for living ring-opening polymerization of lactidescitations
- 2002New bis(imino)pyridine-iron(II)- and cobalt(II)-based catalysts: synthesis characterization and activity towards polymerization of ethylenecitations
- 2002Copolymerization of propene with phenylnorbornene using ansa-bridged metallocene catalystscitations
- 2001Copolymerization of carbon monoxide with exo-methylenecycloalkane and dienes: synthesis of functionalized aliphatic polyketonescitations
- 2000Synthesis and crystal structure of [1-(eta(5)-9-fluorenyl)-2-(eta(5)-1-indenyl)ethane]-hafnium dimethyl
Places of action
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article
Towards improved solubility of poorly water-soluble drugs
Abstract
<p>Amorphous solid dispersions (SDs) open up exciting opportunities in formulating poorly water-soluble active pharmaceutical ingredients (APIs). In the present study, novel catalytic pretreated softwood cellulose (CPSC) and polyvinylpyrrolidone (PVP) were investigated as carrier polymers for preparing and stabilizing cryogenic co-ground SDs of poorly water-soluble piroxicam (PRX). CPSC was isolated from pine wood (Pinus sylvestris). Raman and Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) were used for characterizing the solid-state changes and drug-polymer interactions. High-resolution scanning electron microscope (SEM) was used to analyze the particle size and surface morphology of starting materials and final cryogenic co-ground SDs. In addition, the molecular aspects of drug-polymer interactions and stabilization mechanisms are presented. The results showed that the carrier polymer influenced both the degree of amorphization of PRX and stabilization against crystallization. The cryogenic co-ground SDs prepared from PVP showed an enhanced dissolution rate of PRX, while the corresponding SDs prepared from CPSC exhibited a clear sustained release behavior. In conclusion, cryogenic co-grinding provides a versatile method for preparing amorphous SDs of poorly water-soluble APIs. The solid-state stability and dissolution behavior of such co-ground SDs are to a great extent dependent on the carrier polymer used.</p>