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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Kumar, Pradeep
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Publications (8/8 displayed)
- 2024A flexible dual-band 4 × 4 MIMO antenna for 5G mm-wave 28/38 GHz wearable applicationscitations
- 2024Numerical crashworthiness analysis of 2014 Aluminium- Silicon Carbide Particle (SiCp) foam filled Carbon Fiber-Reinforced Plastic (CFRP) tube under impact loading
- 2024The interplay of topology and antiferromagnetic order in two-dimensional van der Waals crystals of (NixFe1-x)2P2S6citations
- 2023Investigations on effect of pore architectures of additively manufactured novel hydroxyapatite coated PLA/Al<sub>2</sub>O<sub>3</sub> composite scaffold for bone tissue engineering
- 2023Physicochemical investigations of nanoemulsified, curcumin-loaded, crosslinked κ-carrageenan hydrogels
- 2016Analog switching in the nanocolloids of ferroelectric liquid crystalscitations
- 2014An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug delivery
- 2014An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug deliverycitations
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document
Physicochemical investigations of nanoemulsified, curcumin-loaded, crosslinked κ-carrageenan hydrogels
Abstract
<jats:p>Curcumin is a potent drug with several therapeutic benefits; however, its hydrophobicity and rapid metabolism restrict its biomedical application. Nanoemulsions improve the loading and site-specific curcumin delivery, while hydrogels act as a robust delivery vehicle. We synthesized curcumin nanoemulsion-based, crosslinked κ-carrageenan hydrogels using solvent displacement and ionotropic gelation techniques to provide the mutual advantages of nanoemulsions and hydrogels. The crosslinking effect of KCl, CaCl2, and their combination was used to gauge the hydrogels’ water retention, chemical composition, surface topography, and rheological features. The microstructure analysis showed that oil droplets were confined in the polymer network, and FTIR revealed no interaction between κ-carrageenan and curcumin, indicating that curcumin was incorporated within the matrix. The in vitro drug release study interpreted that hydrogels crosslinked with KCl show a better release behavior over others. This study compares the crosslinking efficiencies of KCl, CaCl2, and their combination in improving the curcumin release behavior from the hydrogels.</jats:p>