Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (1/1 displayed)

  • 2024Cardiopulmonary exercise testing in transthyretin amyloid cardiomyopathy patients: a long-term follow-up study4citations

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Rettl, René
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Bonderman, Diana
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Bergler-Klein, Jutta
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Eslam, Roza Badr
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Willixhofer, Robin
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Agostoni, Piergiuseppe
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Kastner, Johannes
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Kammerlander, Andreas
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Duca, Franz
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Binder, Christina
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Ermolaev, Nikita
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Gregshammer, Bernhard
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2024

Co-Authors (by relevance)

  • Rettl, René
  • Bonderman, Diana
  • Bergler-Klein, Jutta
  • Eslam, Roza Badr
  • Willixhofer, Robin
  • Agostoni, Piergiuseppe
  • Kastner, Johannes
  • Kammerlander, Andreas
  • Alasti, Farideh
  • Duca, Franz
  • Binder, Christina
  • Ermolaev, Nikita
  • Gregshammer, Bernhard
OrganizationsLocationPeople

article

Cardiopulmonary exercise testing in transthyretin amyloid cardiomyopathy patients: a long-term follow-up study

  • Rettl, René
  • Kronberger, Christina
  • Bonderman, Diana
  • Bergler-Klein, Jutta
  • Eslam, Roza Badr
  • Willixhofer, Robin
  • Agostoni, Piergiuseppe
  • Kastner, Johannes
  • Kammerlander, Andreas
  • Alasti, Farideh
  • Duca, Franz
  • Binder, Christina
  • Ermolaev, Nikita
  • Gregshammer, Bernhard
Abstract

<jats:sec><jats:title>Aims</jats:title><jats:p>Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) experience reduced functional capacity. We evaluated changes in functional capacity over extensive follow-up using cardiopulmonary exercise testing (CPX).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>ATTR-CM patients underwent CPX and blood testing at baseline, first [V1, 8 (6–10) months] and second follow-up (V2) at 35 (26–41) months after start of disease-specific therapy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We included 34 ATTR-CM patients, aged 77 (±6) years (88.2% men). CPX showed two patterns with functional capacity improvement at V1 and deterioration at V2. Peak work capacity (<jats:italic toggle="yes">P</jats:italic> = 0.005) and peak oxygen consumption (VO<jats:sub>2</jats:sub>, <jats:italic toggle="yes">P</jats:italic> = 0.012) increased at V1 compared with baseline and decreased at V2. The ventilation to carbon dioxide relationship slope (VE/VCO<jats:sub>2</jats:sub>) increased at V2 compared with baseline and V1 (<jats:italic toggle="yes">P</jats:italic> = 0.044). A cut-off for peak VO<jats:sub>2</jats:sub> at 14 ml/kg·min showed more events (composite of death and heart failure hospitalization): less than 14 vs. greater than 14 ml/kg·min (<jats:italic toggle="yes">P</jats:italic> = 0.013). Cut-offs for VE/VCO<jats:sub>2</jats:sub> slope at 40 showed more events greater than 40 vs. less than 40 (<jats:italic toggle="yes">P</jats:italic> = 0.009).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>ATTR-CM patients showed an improvement and deterioration in the short-term and long-term follow-up, respectively, with a better prognosis for those with peak VO<jats:sub>2</jats:sub> above 14 ml/kg·min and for a VE/VCO<jats:sub>2</jats:sub> slope below 40.</jats:p></jats:sec>

Topics
  • Carbon
  • Oxygen
  • laser emission spectroscopy
  • composite
  • size-exclusion chromatography