Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (2/2 displayed)

  • 2023From the phenotype to precision medicine: an update on the cardiomyopathies diagnostic workflow6citations
  • 2021‘Hot phase’ clinical presentation in arrhythmogenic cardiomyopathy115citations

Places of action

Chart of shared publication
Tini, Giacomo
1 / 1 shared
Autore, Camillo
1 / 1 shared
Imazio, Massimo
1 / 1 shared
Biagini, Elena
1 / 1 shared
Canepa, Marco
1 / 1 shared
Gava, Carola Pio Loco Detto
1 / 1 shared
Bauce, Barbara
2 / 3 shared
Parisi, Vanda
1 / 1 shared
Limongelli, Giuseppe
1 / 1 shared
Castelletti, Silvia
1 / 1 shared
Crotti, Lia
1 / 1 shared
Monda, Emanuele
1 / 1 shared
Merlo, Marco
1 / 2 shared
Leoni, Loira
1 / 1 shared
Rigato, Ilaria
1 / 2 shared
Zorzi, Alessandro
1 / 2 shared
Rizzo, Stefania
1 / 1 shared
Cipriani, Alberto
1 / 2 shared
Marinas, Maria Bueno
1 / 1 shared
Lazzari, Manuel De
1 / 1 shared
Rampazzo, Alessandra
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Celeghin, Rudy
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Gaspari, Monica De
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Iliceto, Sabino
1 / 2 shared
Giorgi, Benedetta
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Thiene, Gaetano
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Corrado, Domenico
1 / 2 shared
Pilichou, Kalliopi
1 / 2 shared
Basso, Cristina
1 / 2 shared
Marra, Martina Perazzolo
1 / 2 shared
Chart of publication period
2023
2021

Co-Authors (by relevance)

  • Tini, Giacomo
  • Autore, Camillo
  • Imazio, Massimo
  • Biagini, Elena
  • Canepa, Marco
  • Gava, Carola Pio Loco Detto
  • Bauce, Barbara
  • Parisi, Vanda
  • Limongelli, Giuseppe
  • Castelletti, Silvia
  • Crotti, Lia
  • Monda, Emanuele
  • Merlo, Marco
  • Leoni, Loira
  • Rigato, Ilaria
  • Zorzi, Alessandro
  • Rizzo, Stefania
  • Cipriani, Alberto
  • Marinas, Maria Bueno
  • Lazzari, Manuel De
  • Rampazzo, Alessandra
  • Celeghin, Rudy
  • Gaspari, Monica De
  • Iliceto, Sabino
  • Giorgi, Benedetta
  • Thiene, Gaetano
  • Corrado, Domenico
  • Pilichou, Kalliopi
  • Basso, Cristina
  • Marra, Martina Perazzolo
OrganizationsLocationPeople

article

From the phenotype to precision medicine: an update on the cardiomyopathies diagnostic workflow

  • Tini, Giacomo
  • Autore, Camillo
  • Imazio, Massimo
  • Bariani, Riccardo
  • Biagini, Elena
  • Canepa, Marco
  • Gava, Carola Pio Loco Detto
  • Bauce, Barbara
  • Parisi, Vanda
  • Limongelli, Giuseppe
  • Castelletti, Silvia
  • Crotti, Lia
  • Monda, Emanuele
  • Merlo, Marco
Abstract

<jats:sec><jats:title /><jats:p>Cardiomyopathies are disease of the cardiac muscle largely due to genetic alterations of proteins with ‘structural’ or ‘functional’ roles within the cardiomyocyte, going from the regulation of contraction-relaxation, metabolic and energetic processes to ionic fluxes. Modifications occurring to these proteins are responsible, in the vast majority of cases, for the phenotypic manifestations of the disease, including hypertrophic, dilated, arrhythmogenic and restrictive cardiomyopathies. Secondary nonhereditary causes to be excluded include infections, toxicity from drugs or alcohol or medications, hormonal imbalance and so on. Obtaining a phenotypic definition and an etiological diagnosis is becoming increasingly relevant and feasible, thanks to the availability of new tailored treatments and the diagnostic advancements made particularly in the field of genetics. This is, for example, the case for transthyretin cardiac amyloidosis, Fabry disease or dilated cardiomyopathies due to laminopathies. For these diseases, specific medications have been developed, and a more tailored arrhythmic risk stratification guides the implantation of a defibrillator. In addition, new medications directly targeting the altered protein responsible for the phenotype are becoming available (including the myosin inhibitors mavacantem and aficamten, monoclonal antibodies against Ras-MAPK, genetic therapies for sarcoglycanopathies), thus making a precision medicine approach less unrealistic even in the field of cardiomyopathies. For these reasons, a contemporary approach to cardiomyopathies must consider diagnostic algorithms founded on the clinical suspicion of the disease and developed towards a more precise phenotypic definition and etiological diagnosis, based on a multidisciplinary methodology putting together specialists from different disciplines, facilities for advanced imaging testing and genetic and anatomopathological competencies.</jats:p></jats:sec>

Topics
  • impedance spectroscopy
  • laser emission spectroscopy
  • toxicity
  • size-exclusion chromatography
  • alcohol