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Opric, Dejan
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article
Anxiolytic and antidepressant effect of zinc on rats and its impact on general behavioural parameters
Abstract
<jats:p>Background/Aim. Zinc is an essential element which has considerableinteraction with gamma-aminobutyric acid A type receptors (GABAA) andglutamate receptors in the central nervous system (CNS). It is believed thatzinc acts as a potent inhibitor of glutamate N-methyl-D-aspartate (NMDA)receptors, and binding to structurally specific site on the GABAA receptorleads to inhibition of GABA dependent Cl-pass. The aim of our research was totest the anxiolytic and antidepressant effects of zinc after singleapplication and its influence on general behavioural parameters afterrepeated administration. Methods. Male Wistar rats were treated withincreasing doses of zinc histidine dehydrate (10, 20, 30 mg/kg, i.p.). Todetermine anxiolytic and antidepressant properties of zinc two models wereused: elevated plus maze (EPM) and forced swim test (FST). Behaviouralparameters (stillness and mobility) were, also, recorded after single andrepeated administration of active substance. Results. Testing animals in theEPM showed a statistically significant difference as follows: dose of 20mg/kg significantly increased the time animals spent in open arms, indicatingan acute anxiolytic effect, while doses of 30 mg/kg significantly reduced thetime in the open arms, indicating a potentially anxiogenic effect. Testingthe animals by FST showed a statistically significant difference inimmobility time of animals treated with the lowest applied (10 mg/kg) andhighest applied (30 mg/kg) doses of zinc, compared to the control group. Thefirst day of testing behavioral parameters showed the tendency to increaselocomotor activity of the animals with the lowest dose of zinc (10 mg/kg),while the following day revealed a reduced activity with the highest doseapplied (30 mg/kg). Conclusion. Zinc has important effects on the CNS: Aftersingle application, in all doses zinc showed antidepressant effects. Theeffects of zinc on anxiety and locomotor activity showed dose-dependentbidirectional effects.</jats:p>