• Jadzic, Dragana
• Samardzic, Janko
• Obradovic, Dragan
• Radovanovic, Milan
• Gojkovic-Bukarica, Ljiljana
• Jancic, Jasna
• Scepanovic, Radisav

Abstract

<jats:p>Introduction. The trans-isomer of resveratrol is the active ingredient ofPoligonum cuspidatum, known for its medicinal properties and traditionallyused in the treatment of neuropsychiatric disorders. It is also foundabundantly in the skin of red grapes and red wine. Previous studies havesuggested that trans-resveratrol demonstrates a variety of pharmacologicalactivities including antioxidant, anti-inflammatory, as well asneuroprotective properties and procognitive effects. Objective. The goal ofthe present study was to examine the influence of trans-resveratrol onbehavior in rats and its antidepressant properties. Methods. Male Wistar ratswere treated intraperitoneally (i.p.) with the increasing doses oftrans-resveratrol (5, 10 and 20 mg/kg) or vehicle (dimethyl sulfoxide -DMSO), 30 minutes before testing of the spontaneous locomotor activity orforced swimming. For the experiments, the behavior of the animals wasrecorded by a digital camera, and the data were analyzed by one-way ANOVA,followed by Tukey post-hoc test. Results. Testing of spontaneous locomotoractivity, after the application of vehicle or increasing doses oftrans-resveratrol, showed no statistically significant difference betweengroups (p&gt;0.05). In the forced swim test, one-way ANOVA indicatedstatistically significant effects of trans-resveratrol (p&lt;0.001). Tukeypost-hoc test showed that resveratrol significantly decreased immobility timeat the doses of 10 mg/kg and 20 mg/kg, manifesting the acuteantidepressant-like effects. There were no statistically significantdifferences between the resveratrol treatment of 5 mg/kg and vehicle(p&gt;0.05). Conclusion. The results from our study suggest thattrans-resveratrol produces significant effects in the central nervous system.After single application, it has acute antidepressant effects, but withoutinfluence on locomotor activity.</jats:p>

Topics

• impedance spectroscopy
• experiment